The production of around 2.5 million red blood cells (RBCs) per second in erythropoiesis is one of the most intense activities in the body. It continuously consumes large amounts of iron, approximately 80% of which is recycled from aged erythrocytes. Therefore, similar to the “making”, the “breaking” of red blood cells is also very rapid and represents one of the key processes in mammalian physiology. Under steady-state conditions, this important task is accomplished by specialized macrophages, mostly liver Kupffer cells (KCs) and splenic red pulp macrophages (RPMs). It relies to a large extent on the engulfment of red blood cells via so-called erythrophagocytosis. Surprisingly, we still understand little about the mechanistic details of the removal and processing of red blood cells by these specialized macrophages. We have only started to uncover the signaling pathways that imprint their identity, control their functions and enable their plasticity. Recent findings also identify other myeloid cell types capable of red blood cell removal and establish reciprocal cross-talk between the intensity of erythrophagocytosis and other cellular activities. Here, we aimed to review the multiple and emerging facets of iron recycling to illustrate how this exciting field of study is currently expanding.

Patryk Slusarczyk

Katarzyna Mleczko-Sanecka

Genes

GENES (ISSN 2073-4425) 是一本经过同行评审的国际开放获取期刊，为与基因、遗传学和基因组学相关的研究提供了一个高级论坛。它发表评论、研究文章、通讯和技术说明。论文的长度没有限制，我们鼓励科学家尽可能详细地发表他们的结果。

GENES (ISSN 2073-4425) is a peer-reviewed international open-access journal that provides a high-level forum for research related to genes, genetics, and genomics. It publishes comments, research articles, communications, and technical notes. There is no restriction on the length of papers, and we encourage scientists to present their results as comprehensively as possible.

《Genes》（ISSN 2073-4425）是一本经过同行评审的国际开放获取期刊，专注于基因、遗传学和基因组学相关研究。期刊为研究者提供了一个高级论坛，发表内容包括评论、研究文章、通讯和技术说明。论文长度没有限制，我们鼓励科学家尽可能详细地分享他们的研究成果。

The Multiple Facets of Iron Recycling

The multiple and emerging facets of iron recycling are reviewed to illustrate how this exciting field of study is currently expanding.

Category	Quartile
生物学	3
生物学, 遗传学	3

The Multiple Facets of Iron Recycling

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Journal Info

Category	Quartile
GENETICS & HEREDITY	2