Forkhead transcription factors of the FoxO family have important roles in cellular proliferation, apoptosis, differentiation and stress resistance. FoxO proteins also play important roles in metabolism of complex organisms. FoxO1 regulates glucose and lipid metabolism in liver, as well as preadipocyte, myoblast and vascular endothelial cell differentiation. In the hypothalamus, FoxO controls food intake. In this chapter, we review the role of FoxO in pancreatic β cells. Pancreatic β cells secrete insulin to maintain the plasma glucose levels in a strict physiological range. Defects of β cell function cause diabetes. The expression pattern of FoxO1 during pancreatic organogenesis is similar to that of Pdx1, Nkx2.2 and Pax4, transcription factors known to be critical for β cell development. FoxO1 is expressed in a subset of pancreatic duct cells, in which insulin and/or Pdx1 are occasionally expressed. FoxO1 inhibits β cell proliferation through suppression of Pdx1 by competing with FoxA2 and protects against β cell failure induced by oxidative stress through NeuroD and MafA induction. Thus, a series of FoxO1 studies in pancreas suggested that FoxO1 plays important roles in pancreatic β cell differentiation, neogenesis, proliferation and stress resistance. Genetic or pharmacological manipulation of FoxO can be used to prevent β cell failure or aid in the differentiation of uncommitted endocrine progenitors into β cells for transplantation.

Tadahiro KITAMURA

Yukari IDO KITAMURA

Endocrine Journal

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Role of FoxO Proteins in Pancreatic .BETA. Cells

The role of FoxO1 plays important roles in pancreatic β cell differentiation, neogenesis, proliferation and stress resistance, which can be used to prevent β cell failure or aid in the differentiation of uncommitted endocrine progenitors into β cells for transplantation.

Category	Quartile
医学	4
医学, 内分泌学与代谢	4

Role of FoxO Proteins in Pancreatic .BETA. Cells

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Journal Info

Category	Quartile
ENDOCRINOLOGY & METABOLISM	4