Abstract Resting state fMRI (rs‐fMRI) provides an excellent platform for examining the amplitude of low frequency fluctuations (ALFF) and fractional amplitude of low frequency fluctuations (fALFF), which are key indices of brain functioning. However, ALFF and fALFF have been used only sporadically to study autism. rs‐fMRI data from 69 children (40 autistic, mean age = 8.47 ± 2.20 years; age range: 5.2 to 13.2; and 29 non‐autistic, mean age = 9.02 ± 1.97 years; age range 5.9 to 12.9) were obtained from the Autism Brain Imaging Data Exchange (ABIDE II). ALFF and fALFF were measured using CONN connectivity toolbox and SPM12, at whole‐brain &amp; network‐levels. A two‐sampled t ‐test and a 2 Group (autistic, non‐autistic) × 7 Networks ANOVA were conducted to test group differences in ALFF and fALFF. The whole‐brain analysis identified significantly reduced ALFF values for autistic participants in left parietal opercular cortex, precuneus, and right insula. At the network level, there was a significant effect of diagnostic group and brain network on ALFF values, and only significant effect of network, not group, on fALFF values. Regression analyses indicated a significant effect of age on ALFF values of certain networks in autistic participants. Such intrinsically different network‐level responses in autistic participants may have implications for task‐level recruitment and synchronization of brain areas, which may in turn impact optimal cognitive functioning. Moreover, differences in low frequency fluctuations of key networks, such as the DMN and SN, may underlie alterations in brain responses in autism that are frequently reported in the literature.

Smitha Karavallil Achuthan

Kelly L. Coburn

Meagan E. Beckerson

Rajesh K. Kana

Autism Research

自闭症研究将涵盖被称为普遍性发育障碍（或自闭症谱系障碍 - ASD）的发育障碍。该杂志侧重于基本的遗传、神经生物学和心理机制，以及这些机制如何影响 ASD 的发育过程。

The journal "Autism Research" focuses on the study of Autism Spectrum Disorder (ASD), a pervasive developmental disorder. It covers fundamental research in genetics, neurobiology, and psychological mechanisms, examining how these mechanisms influence the developmental processes of ASD.

《Autism Research》期刊专注于自闭症谱系障碍（ASD）这一普遍性发育障碍的研究。该杂志涵盖遗传学、神经生物学和心理机制等基础研究，探讨这些机制如何影响ASD的发展过程。

Amplitude of low frequency fluctuations during resting state <scp>fMRI</scp> in autistic children

Resting state fMRI data revealed significantly reduced ALFF values for autistic participants in left parietal opercular cortex, precuneus, and right insula, and differences in low frequency fluctuations of key networks, such as the DMN and SN, may underlie alterations in brain responses in autism that are frequently reported in the literature.

Category	Quartile
医学	2
医学, 行为科学	1
医学, 心理学发育	2

Amplitude of low frequency fluctuations during resting state fMRI in autistic children

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Category	Quartile
PSYCHOLOGY, DEVELOPMENTAL	1