L-arginine plays an important role in immune regulation by affecting the immune response and inflammation. This meta-analysis was performed to assess whether L-arginine supplementation could improve the outcomes of immune function, and to evaluate the safety of L-arginine supplementation. Four databases (PubMed, EMBASE, Web of Science, the Cochrane Library) for all randomized controlled trials investigating the effects of supplementation with L-arginine published from 1966 to September 2013 were searched. The quality of controlled trials was assessed with the Jadad method. Meta-analyses were performed with fixed- or random-effects models according to heterogeneity of studies. Data from 11 trials involving 321 patients were enrolled. Meta-analysis showed that the L-arginine supplement group had a significantly greater CD4⁺ T-cell proliferation response (MD 5.03; 95% CI 1.11, 8.95; p<0.05), and that the incidence of infectious complications was lower (OR 0.40; 95% CI 0.17, 0.95; p<0.05) than control.L-精氨酸通过影响机体免疫应答和炎症反应在免疫调节中发挥重要作用。本 meta 分析对补充L-精氨酸是否可以改善机体免疫功能的结果进行了评估，同 时对补充L-精氨酸的安全性进行了评价。本文检索了四个数据库（PubMed, EMBASE , Web of Science, the Cochrane Library）中自1966 至2013 年9 月发 表的有关补充L-精氨酸对免疫功能影响的所有随机对照试验。按照Jadad 评分 量表对纳入的随机对照研究进行方法学质量评定，并根据异质性检验的结果， 选择使用固定或随机效应模型。最终11 项试验（包括321 名患者）被纳入本 次研究。Meta 分析结果显示，与对照组相比，L-精氨酸组CD4+ T 细胞的增殖 显著增加（MD 5.03; 95% CI 1.11, 8.95; p<0.05），且感染并发症的发生率降低 （OR 0.40; 95% CI 0.17, 0.95; p<0.05）。

Kai Kang

Xiao-Liang Shu

Jing-Xia Zhong

Ting-Ting Yu

Asia Pacific Journal of Clinical Nutrition

《亚太临床营养学杂志》（APJCN）旨在发表高质量的临床营养相关研究成果，以培养该地区临床营养学家的能力，加强人类营养学和相关学科在健康促进和疾病预防方面的实践。 APJCN 将发表原创研究报告、评论、简短交流和案例报告。新闻、书评和其他项目也将包括在内。所有论文的接受标准是研究的质量和原创性及其对我们读者的意义。除非另有说明，稿件由至少两名匿名审稿人和编辑进行同行评审。编辑委员会保留拒绝任何材料发表的权利，并建议作者保留提交的手稿和信件的副本，因为材料不能退还。最终接受或拒绝取决于编辑委员会

The Asia Pacific Journal of Clinical Nutrition aims to publish high-quality research findings related to clinical nutrition, enhancing the capabilities of clinical nutritionists in the region and strengthening the practice of human nutrition and related disciplines in health promotion and disease prevention. The journal will publish original research articles, reviews, brief communications, and case reports, as well as news, book reviews, and other items. The acceptance criteria for all submissions are based on the quality and originality of the research and its significance to our readers. Unless otherwise stated, all manuscripts will undergo peer review by at least two anonymous reviewers and the editor. The editorial board reserves the right to reject any material for publication and advises authors to retain copies of submitted manuscripts and correspondence, as materials cannot be returned. The final decision on acceptance or rejection rests with the editorial board.

《亚太临床营养学杂志》（Asia Pacific Journal of Clinical Nutrition）旨在发表高质量的临床营养相关研究成果，以提升该地区临床营养学家的专业能力，并加强人类营养学及相关学科在健康促进和疾病预防方面的实践。该期刊将发表原创研究报告、评论、简短交流和案例报告，同时也会包括新闻、书评及其他相关内容。所有稿件的接受标准基于研究的质量、原创性及其对读者的意义。除非另有说明，所有稿件将由至少两名匿名审稿人和编辑进行同行评审。编辑委员会保留拒绝任何材料发表的权利，并建议作者保留提交的手稿和信件的副本，因为提交的材料将不予退还。最终的接受或拒绝决定由编辑委员会作出。

Effect of L-arginine on immune function: a meta-analysis.

This meta-analysis showed that the L-arginine supplement group had a significantly greater CD4⁺ T-cell proliferation response than control, and that the incidence of infectious complications was lower than control.

Category	Quartile
医学	4
医学, 营养学	4

Effect of L-arginine on immune function: a meta-analysis.

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Journal Info

Category	Quartile
NUTRITION & DIETETICS	4