Syngas fermentation to ethanol has reached industrial production. Further improvement of this process would be aided by quantitative understanding of the influence of imposed reaction conditions on the fermentation performance. That requires a reliable model of the microbial kinetics. Data were collected from 37 steady states in chemostats and from many batch experiments that use Clostridium authoethanogenum. Biomass-specific rates from CO conversion experiments were related to each other according to simple reaction stoichiometries and the Pirt equation, with only the ratio of ethanol to acetate production remaining as degree of freedom. No clear dependency of this ratio on dissolved concentrations, such as CO or acetic acid concentration, was found. This is largely caused by the lack of knowledge about the dependency of the CO uptake rate (and hence all other rates) on the CO concentration. This knowledge gap is caused by a lack of dissolved CO measurements. For dissolved H2, a similar gap applies. Modelling H2 consumption adds more degrees of freedom to the system, so that more structured experiments with H2 is needed. The inhibition of gas consumption by acetate and ethanol is partly known but needs further study. KEY POINTS: • Set of Clostridium autoethanogenum syngas fermentation data from chemostats. • Unstructured kinetic models can relate most biomass-specific rates to dilution rates. • Lack of dissolved gas measurements limits deeper understanding.

Iris Kerkhof

Lars Puiman

Adrie J J Straathof

Applied Microbiology and Biotechnology

应用微生物学和生物技术专注于原核或真核细胞、相关酶和蛋白质；应用遗传学和分子生物技术；基因组学和蛋白质组学；应用微生物和细胞生理学；环境生物技术；工艺和产品等等。该杂志欢迎对新兴产品、工艺和技术的长篇论文和小型评论。

The journal "Applied Microbiology and Biotechnology" focuses on the study of prokaryotic and eukaryotic cells, related enzymes and proteins; applied genetics and molecular biotechnology; genomics and proteomics; applied microbiology and cell physiology; environmental biotechnology; as well as processes and products. The journal welcomes full-length papers and short reviews on emerging products, processes, and technologies.

《Applied Microbiology and Biotechnology》期刊专注于原核和真核细胞、相关酶和蛋白质的研究；应用遗传学和分子生物技术；基因组学和蛋白质组学；应用微生物学和细胞生理学；环境生物技术；以及工艺和产品等领域。该期刊欢迎关于新兴产品、工艺和技术的长篇论文和小型评论。

Category	Quartile
生物学	3
生物学, 生物工程与应用微生物	3

Understanding microbial syngas fermentation rates

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Category	Quartile
BIOTECHNOLOGY & APPLIED MICROBIOLOGY	2