Osteoarthritis (OA) is a disease that involves the entire joint, but its pathophysiology is not well described. Alterations in peri-articular bone are an integral part of the OA disease process and different aspects of bone changes have been described in different patient (sub)groups and animal models. In this review we will discuss the osteoarthritis pathophysiology from the perspective of periarticular bone changes, which can be considered at three hierarchical levels: the bone (or joint) shape, the subchondral bone architecture and its cellular and molecular phenotype. In this review we try to provide an overview of the current knowledge of peri-articular bone changes in OA and what it could possibly imply for the initiation of OA and its progression. This article is part of a Special Issue entitled "Osteoarthritis".

H Weinans

M Siebelt

R Agricola

S M Botter

T M Piscaer

J H Waarsing

Bone

BONE 是一个跨学科论坛，用于快速发表有关骨和矿物质代谢的基础、转化和临床方面的原创文章和评论。该杂志还鼓励提交有关骨骼与其他器官系统相互作用的论文，包括软骨、内分泌、肌肉、脂肪、神经、血管、胃肠道、造血和免疫系统。特别注意将实验研究应用于临床实践。

BONE is an interdisciplinary forum dedicated to the rapid publication of original articles and reviews concerning the fundamental, translational, and clinical aspects of bone and mineral metabolism. The journal also encourages submissions on the interactions between bone and other organ systems, including cartilage, endocrine, muscle, fat, nerve, vascular, gastrointestinal, hematopoietic, and immune systems. Special emphasis is placed on applying experimental research to clinical practice.

BONE 是一个跨学科的论坛，旨在快速发表关于骨骼和矿物质代谢的基础研究、转化研究和临床研究的原创文章和评论。该杂志还鼓励提交关于骨骼与其他器官系统相互作用的论文，包括软骨、内分泌、肌肉、脂肪、神经、血管、胃肠道、造血和免疫系统。特别关注将实验研究应用于临床实践。

Pathophysiology of peri-articular bone changes in osteoarthritis.

The current knowledge of peri-articular bone changes in OA is provided and what it could possibly imply for the initiation of OA and its progression is provided.

Category	Quartile
医学	2
医学, 内分泌学与代谢	2

Pathophysiology of peri-articular bone changes in osteoarthritis.

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Journal Info

Category	Quartile
ENDOCRINOLOGY & METABOLISM	2