For many years, pharmaceutical therapies for osteoarthritis (OA) were focused on cartilage. However, it has been theorized that bone changes such as increased bone volume fraction and decreased bone matrix mineralization may play an important role in the initiation and pathogenesis of OA as well. The mechanisms behind the bone changes are subject of debate, and a better understanding may help in the development of bone-targeting OA therapies. In the literature, the increase in bone volume fraction has been hypothesized to result from mechanoregulated bone adaptation in response to decreased mineralization. Furthermore, both changes in bone volume fraction and mineralization have been reported to be highest close to the cartilage, and bone volume fraction has been reported to be correlated with cartilage degeneration. These data indicate that cartilage degeneration, bone volume fraction, and bone matrix mineralization may be related in OA. In the current study, we aimed to investigate the relationships between cartilage degeneration, bone matrix mineralization and bone volume fraction at a local level. With microCT, we determined bone matrix mineralization and bone volume fraction as a function of distance from the cartilage in osteochondral plugs from human OA tibia plateaus with varying degrees of cartilage degeneration. In addition, we evaluated whether mechanoregulated bone adaptation in response to decreased bone matrix mineralization may be responsible for the increase in bone volume fraction observed in OA. For this purpose, we used the experimentally obtained mineralization data as input for bone adaptation simulations. We simulated the effect of mechanoregulated bone adaptation in response to different degrees of mineralization, and compared the simulation results to the experimental data. We found that local changes in subchondral bone mineralization and bone volume fraction only occurred underneath severely degenerated cartilage, indicating that bone mineralization and volume fraction are related to cartilage degeneration at a local level. In addition, both the experimental data and the simulations indicated that a depth-dependent increase in bone volume fraction could be caused by decreased bone matrix mineralization. However, a quantitative comparison showed that decreased mineralization can only explain part of the subchondral sclerosis observed in OA.

L G E Cox

C C van Donkelaar

B van Rietbergen

P J Emans

K Ito

Bone

BONE 是一个跨学科论坛，用于快速发表有关骨和矿物质代谢的基础、转化和临床方面的原创文章和评论。该杂志还鼓励提交有关骨骼与其他器官系统相互作用的论文，包括软骨、内分泌、肌肉、脂肪、神经、血管、胃肠道、造血和免疫系统。特别注意将实验研究应用于临床实践。

BONE is an interdisciplinary forum dedicated to the rapid publication of original articles and reviews concerning the fundamental, translational, and clinical aspects of bone and mineral metabolism. The journal also encourages submissions on the interactions between bone and other organ systems, including cartilage, endocrine, muscle, fat, nerve, vascular, gastrointestinal, hematopoietic, and immune systems. Special emphasis is placed on applying experimental research to clinical practice.

BONE 是一个跨学科的论坛，旨在快速发表关于骨骼和矿物质代谢的基础研究、转化研究和临床研究的原创文章和评论。该杂志还鼓励提交关于骨骼与其他器官系统相互作用的论文，包括软骨、内分泌、肌肉、脂肪、神经、血管、胃肠道、造血和免疫系统。特别关注将实验研究应用于临床实践。

Decreased bone tissue mineralization can partly explain subchondral sclerosis observed in osteoarthritis.

It is found that local changes in subchondral bone mineralization and bone volume fraction only occurred underneath severely degenerated cartilage, indicating that bone Mineralization and volume fraction are related to cartilage degeneration at a local level.

Category	Quartile
医学	2
医学, 内分泌学与代谢	2

Decreased bone tissue mineralization can partly explain subchondral sclerosis observed in osteoarthritis.

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Journal Info

Category	Quartile
ENDOCRINOLOGY & METABOLISM	2