The homeostasis of cellular proteins, or proteostasis, is critical for neuronal function and for brain processes, including learning and memory. Increasing evidence indicates that defective proteostasis contributes to the progression of neurodegenerative disorders, including Alzheimer's disease (AD), the most prevalent form of dementia in the elderly. Proteostasis comprises a set of cellular mechanisms that control protein synthesis, folding, post-translational modification and degradation, all of which are deregulated in AD. Importantly, deregulation of proteostasis plays a key role in synapse dysfunction and in memory impairment, the major clinical manifestation of AD. Here, we discuss molecular pathways involved in protein synthesis and degradation that are altered in AD, and possible pharmacological approaches to correct these defects.

Danielle Cozachenco

Felipe C Ribeiro

Sergio T Ferreira

Ageing research reviews

随着人类平均预期寿命的增加，老龄化和与年龄有关的疾病对我们社会的影响也在增加。衰老研究现在是数千个实验室的重点，其中包括遗传学、分子和细胞生物学、生物化学和行为领域的领导者。老龄化研究评论 (ARR) 涵盖了该领域的趋势。它旨在填补一个巨大的空白，即对衰老机制和与年龄相关的疾病的新发现进行批判性评论和观点的来源。对控制细胞增殖、分化和存活的机制理解的快速进展正在导致对衰老调控的新认识。从端粒酶到干细胞，再到能量和氧自由基代谢，这是衰老研究多学科领域令人兴奋的新时代。正在确定延长寿命的操作的细胞和分子基础，例如热量限制，并且正在开发预防与年龄有关的疾病的新方法。 ARR 发表的文章选自衰老研究的广泛领域，重点关注衰老过程的细胞和分子机制以及与年龄相关的疾病，如癌症、心血管疾病、糖尿病和神经退行性疾病。本期刊还介绍了基础衰老研究在延长寿命和预防疾病方面的应用。

As the average life expectancy of humans increases, the impact of aging and age-related diseases on our society is also growing. Aging research has now become a focal point for thousands of laboratories, including leaders in genetics, molecular and cellular biology, biochemistry, and behavioral sciences. Ageing Research Reviews aims to fill a significant gap by providing critical reviews and perspectives on new discoveries related to aging mechanisms and age-related diseases. Rapid advancements in understanding the mechanisms that control cell proliferation, differentiation, and survival are leading to new insights into aging regulation. From telomerase to stem cells, and energy and oxidative metabolism, we are entering an exciting new era in the multidisciplinary field of aging research. The cellular and molecular basis for interventions to extend lifespan, such as caloric restriction, is being identified, and new approaches to prevent age-related diseases are being developed. Articles published in Ageing Research Reviews cover a wide range of topics in aging research, focusing on the cellular and molecular mechanisms of the aging process and age-related diseases such as cancer, cardiovascular diseases, diabetes, and neurodegenerative disorders. This journal also discusses the applications of fundamental aging research in extending lifespan and preventing diseases.

随着人类平均预期寿命的延长，老龄化及与年龄相关的疾病对社会的影响日益显著。衰老研究已成为数千个实验室的研究重点，涵盖遗传学、分子与细胞生物学、生物化学及行为科学等多个领域的前沿成果。《Ageing Research Reviews》旨在填补对衰老机制及与年龄相关疾病新发现的批判性评论和观点的空白。对控制细胞增殖、分化和存活机制的深入理解，正在推动我们对衰老调控的新认识。从端粒酶、干细胞到能量和氧自由基代谢，衰老研究正迎来一个多学科交叉的激动人心的新时代。研究者们正在探索延长寿命的细胞和分子基础，例如热量限制，并开发预防与年龄相关疾病的新方法。《Ageing Research Reviews》发表的文章涵盖衰老研究的广泛领域，重点关注衰老过程的细胞和分子机制，以及与年龄相关的疾病，如癌症、心血管疾病、糖尿病和神经退行性疾病。此外，本期刊还探讨基础衰老研究在延长寿命和预防疾病方面的应用。

Ageing Research Reviews

Ageing Res Rev

Defective proteostasis in Alzheimer's disease.

Molecular pathways involved in protein synthesis and degradation that are altered in AD are discussed, and possible pharmacological approaches to correct these defects are discussed.

Category	Quartile
医学	1
医学, 老年医学	1
医学, 细胞生物学	2

Defective proteostasis in Alzheimer's disease.

ivySCI AI Smartly Parses PDF, Answers Researchers' Questions, and Helps You Understand Papers in Seconds

Journal Info

Category	Quartile
GERIATRICS & GERONTOLOGY	1