This review paper discusses the key aspects of ocular biopharmaceutics, with emphasis on the crucial role played by ocular compartmental modelling and simulation in deciphering physiological conditions related to various eye diseases. It describes eye's intricate structure and function and the need for precise and targeted drug delivery systems to address prevalent eye conditions. The review categorizes and discusses various formulations employed in ocular drug delivery, delineating their respective advantages and limitations. Additionally, it probes the challenges inherent in diverse routes of drug administration for ocular therapies and provides insights into the complexities of achieving optimal drug concentrations at the target site within the eye. The central theme of this work is the ocular compartmental modelling and simulations. Hence, this works discusses on the nuanced understanding of physiological conditions within the eye, drug distribution, drug release kinetics, and key considerations for ocular compartmental modelling and simulations. By combining information from various sources, this review aims to serve as a comprehensive reference for researchers, clinicians, and pharmaceutical developers. It covers the multifaceted landscape of ocular biopharmaceutics and the transformative impact of modelling and simulation in optimizing ocular drug delivery strategies.

Mohammed Shareef Khan

Aditya Murthy

Tausif Ahmed

AAPS PharmSciTech

AAPS PHARMSCITECH 是一份经过同行评审的在线期刊，致力于为那些对药物剂型和递送系统的研究、开发和评估感兴趣的药物科学家和工程师提供服务，包括来自生物技术的药物和与商业化有关的制造科学这种剂型。由于其电子性质，AAPS PHARMSCITECH 渴望利用不断发展的电子技术来实现更快、更多样化的信息传递机制。欢迎提交不请自来的专家评论和研究文章。

AAPS PharmSciTech is a peer-reviewed online journal dedicated to serving pharmaceutical scientists and engineers interested in the research, development, and evaluation of drug formulations and delivery systems, including those related to biotechnology and manufacturing sciences associated with commercialization. Due to its electronic nature, AAPS PharmSciTech aims to leverage evolving electronic technologies to facilitate faster and more diverse information dissemination. We welcome unsolicited expert reviews and research articles.

AAPS PharmSciTech 是一本经过同行评审的在线期刊，专注于药物剂型和递送系统的研究、开发与评估，服务于药物科学家和工程师，尤其是涉及生物技术药物和商业化制造科学的领域。由于其电子出版的特性，AAPS PharmSciTech 希望利用不断发展的电子技术，实现更快速和多样化的信息传播。我们欢迎专家提交评论和研究文章。

Category	Quartile
医学	4
医学, 药学	4

Advancements in Ocular Modelling and Simulations: Key Considerations and Case Studies

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Journal Info

Category	Quartile
PHARMACOLOGY & PHARMACY	2