Abstract Macroautophagy, a universal cellular process, sends cellular material to lysosomes for breakdown and is often activated by stressors like hypoxia or drug exposure. It is vital for protein balance, neurotransmitter release, synaptic function, and neuron survival. The role of macroautophagy in substance use disorders is dual. On one hand, substances like cocaine, methamphetamine, opiates, and alcohol can activate macroautophagy pathways to degrade various neuroinflammatory factors in neuronal cells, providing a protective function. On the other hand, long‐term and excessive use of addictive substances can inhibit macroautophagy pathways, obstructing the fusion of autophagosomes with lysosomes and losing the original protective function. This review first summarizes the key proteins and signaling pathways involved in macroautophagy, including mTORC1, AMPK, and endoplasmic reticulum stress, and suggests that the regulation of macroautophagy plays a central role in drug‐rewarding behavior and addiction. Second, we focus on the interactions between macroautophagy and neuroinflammation induced by drugs, evaluating the potential of macroautophagy modulators as therapeutic strategies for substance use disorder (SUD), and identifying autophagy‐related biomarkers that can be used for early diagnosis and monitoring of treatment response. Our review summarizes the important scientific basis involved in macroautophagy pathways for the development of new therapies for SUD.

Zhaoying Yu

Shujun Lin

Xinshuang Gong

Zhiting Zou

Xiangdong Yang

Yuer Ruan

Liyin Qian

Yu Liu

Zizhen Si

Annals of the New York Academy of Sciences

代表纽约科学院出版的《纽约科学院年鉴》为当前科学兴趣的研究提供了多学科视角，对更广泛的科学界和整个社会具有深远的影响。在新兴发展提供新见解的承诺之际，每期特刊都汇集了该研究领域关键贡献者的最佳思想。个别主题的年鉴特刊通过提供一个中立的讨论论坛——在许多机构和领域内和跨领域，激发了思考科学的新方式。

The Annals of the New York Academy of Sciences is a journal published by the New York Academy of Sciences that offers a multidisciplinary perspective on current scientific research interests, having a profound impact on the broader scientific community and society as a whole. Each special issue gathers the best thoughts from key contributors in the field, committed to providing new insights into emerging developments. The annual special issues on individual topics serve as a neutral discussion forum, stimulating new ways of thinking about science across various institutions and disciplines.

《Annals of the New York Academy of Sciences》是由纽约科学院出版的期刊，提供了多学科视角，关注当前科学研究的热点问题，对科学界和社会产生了深远的影响。每期特刊汇集了该研究领域内关键贡献者的最佳思想，承诺为新兴发展提供新的见解。个别主题的年鉴特刊通过提供一个中立的讨论论坛，激发了跨领域的科学思考，促进了不同机构和领域之间的交流。

Category	Quartile
综合性期刊	3
综合性期刊, 综合性期刊	3

The role of macroautophagy in substance use disorders

ivySCI AI Smartly Parses PDF, Answers Researchers' Questions, and Helps You Understand Papers in Seconds

Journal Info

Category	Quartile
MULTIDISCIPLINARY SCIENCES	1