Abstract The fine structures, enzyme histochemical, and immunohistochemical characterization of liver in zebrafish were investigated using light microscopy and electron microscopy. The results showed that liver was separated into three lobes and each lobe had a central vessel comparable to the mammalian central vein. However typical hepatic lobules, portal areas, and hepatic arteries were not observed. A portal vein entered the liver and its tributaries were connected directly to the sinusoids, which then converged to the central vessel. Three central vessels in lobes finally carried the blood out of liver. The polygonal and bilayered hepatocytes were arranged as twisting, branching, and anastomosing cords. Ultrastructurally, they showed apparent morphological features of protein synthesis and secretion. Bile entered the biliary tree through the intracellular canaliculus, the ramifications of intercellular canaliculi that originated near the hepatic nucleus and then extended to the hepatocyte surface where two adjacent hepatocyte membranes formed intercellular canaliculi, and then ran sequentially through bile preductules, bile ductules, and bile ducts to be secreted out of the liver. Bile preductular epithelial cells (BPs) were cells located between bilayered hepatocytes in one hepatic cord. Occasionally, some tight junctions were detected forming the link between BPs and hepatocytes, which led us to assume that BPs might have a close relationship with hepatocytes during evolution. The present results indicate that zebrafish liver has its own specific fine structure. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.

Yilin Yao

Jinxing Lin

Ping Yang

Qiusheng Chen

Xiaohong Chu

Cheng Gao

Jianhua Hu

The Anatomical Record

The Anatomical Record is a journal dedicated to anatomical research, covering various fields related to anatomy. It aims to provide researchers with a platform to communicate and share the latest research findings.

《Anatomical Record》是一本专注于解剖学研究的期刊，涵盖了与解剖学相关的各个领域，旨在为研究者提供一个交流和分享最新研究成果的平台。

Category	Quartile
医学	4
医学, 解剖学与形态学	4

Fine Structure, Enzyme Histochemistry, and Immunohistochemistry of Liver in Zebrafish

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Journal Info

Category	Quartile
ANATOMY & MORPHOLOGY	2