ALSUntangled reviews alternate and off-label treatments prompted by patient interest. Here, we review psilocybin, a chemical derived from mushrooms and belonging in the category of drugs known as psychedelics. Psilocybin has plausible mechanisms for slowing ALS progression because of its ability to cross the blood brain barrier and effect neurogenesis and inflammation. Currently, there are no pre-clinical ALS models, case reports, or trials for psilocybin and ALS in the context of disease modifying therapy. Depending on dosing, there can be a high risk of psychological side effects including hallucinations and physical harm. Based on the above information, we do not currently support the use of psilocybin as a means to slow ALS progression.

Bhavya Bakshi

Sandeep Yerraguntla

Carmel Armon

Paul Barkhaus

Tulio Bertorini

Robert Bowser

Sarah Breevoort

Mark Bromberg

Andrew Brown

Gregory T. Carter

Vincent Chang

Jesse Crayle

Timothy Fullam

Maxwell Greene

Terry Heiman-Patterson

Carlayne Jackson

Sartaj Jhooty

Elise Mallon

Javier Mascias Cadavid

Christopher J. Mcdermott

Gary Pattee

Kaitlyn Pierce

Dylan Ratner

Yuyao Sun

Olivia Wang

Paul Wicks

Martina Wiedau

Richard Bedlack

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

肌萎缩侧索硬化和额颞叶变性是一项令人兴奋的新举措。它代表了《肌萎缩侧索硬化》杂志的及时扩展，以应对 ALS 和额颞叶痴呆之间的临床、影像学病理和遗传重叠。扩展后的期刊对与运动神经元疾病相关的广泛问题的研究提供了出色的报道，特别是 ALS（LOU GEHRIG 病）和与额颞叶退化相关的认知衰退。该杂志还涵盖了与这些核心疾病相关的神经轴疾病。

The journal "Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration" is an exciting new initiative that represents a timely expansion of the journal "Amyotrophic Lateral Sclerosis" to address the clinical, imaging pathological, and genetic overlaps between ALS and frontotemporal dementia. The expanded journal provides excellent coverage of a wide range of issues related to motor neuron diseases, with a particular focus on ALS (Lou Gehrig's disease) and cognitive decline associated with frontotemporal degeneration. Additionally, the journal covers research related to neuroaxial diseases associated with these core conditions.

《Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration》是一个令人兴奋的新期刊，旨在扩展《肌萎缩侧索硬化》杂志，以应对肌萎缩侧索硬化（ALS）和额颞叶痴呆之间的临床、影像学病理和遗传重叠。该期刊提供了对与运动神经元疾病相关的广泛问题的深入研究，特别关注ALS（又称卢·盖里希病）及其与额颞叶退化相关的认知衰退。此外，期刊还涵盖了与这些核心疾病相关的神经轴疾病的研究。

ALSUntangled #77: Psilocybin

ALSUntangled 第77期：裸盖菇素

Category	Quartile
医学	4
医学, 临床神经病学	4

ALSUntangled #77: Psilocybin

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Journal Info

Category	Quartile
CLINICAL NEUROLOGY	2