Blood vessels form a versatile transport network that is best known for its critical roles in processes such as tissue oxygenation, metabolism and immune surveillance. The vasculature also provides local, often organ-specific, molecular signals that control the behaviour of other cell types in their vicinity during development, homeostasis and regeneration, and also in disease processes. In the skeletal system, the local vasculature is actively involved in both bone formation and resorption. In addition, blood vessels participate in inflammatory processes and contribute to the pathogenesis of diseases that affect the joints, such as rheumatoid arthritis and osteoarthritis. This Review summarizes the current understanding of the architecture, angiogenic growth and functional properties of the bone vasculature. The effects of ageing and pathological conditions, including arthritis and osteoporosis, are also discussed.

Jan Tuckermann

Ralf H Adams

Nature reviews. Rheumatology

期刊范围涵盖风湿病研究的整个范围。我们确保我们的文章可供最广泛的受众访问。

Nature Reviews Rheumatology covers the entire spectrum of rheumatology research. We are committed to ensuring that our articles are accessible to the widest possible audience.

《Nature Reviews Rheumatology》期刊涵盖了风湿病研究的各个领域。我们致力于确保我们的文章能够被最广泛的受众所访问。

Nature Reviews Rheumatology

Nat Rev Rheumatol

The endothelium-bone axis in development, homeostasis and bone and joint disease.

This Review summarizes the current understanding of the architecture, angiogenic growth and functional properties of the bone vasculature and highlights the roles of endothelial cells during bone development, homeostasis and disease.

Category	Quartile
医学	1
医学, 风湿病学	1

The endothelium-bone axis in development, homeostasis and bone and joint disease.

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