The family of resistin-like molecules (RELMs) consists of four members in rodents (RELMα/FIZZ1/HIMF, RELMβ/FIZZ2, Resistin/FIZZ3, and RELMγ/FIZZ4) and two members in humans (Resistin and RELMβ), all of which exhibit inflammation-regulating, chemokine, and growth factor properties. The importance of these cytokines in many aspects of physiology and pathophysiology, especially in cardiothoracic diseases, is rapidly evolving in the literature. In this review article, we attempt to summarize the contribution of RELM signaling to the initiation and progression of lung diseases, such as pulmonary hypertension, asthma/allergic airway inflammation, chronic obstructive pulmonary disease, fibrosis, cancers, infection, and other acute lung injuries. The potential of RELMs to be used as biomarkers or risk predictors of these diseases also will be discussed. Better understanding of RELM signaling in the pathogenesis of pulmonary diseases may offer novel targets or approaches for the development of therapeutics to treat or prevent a variety of inflammation, tissue remodeling, and fibrosis-related disorders in respiratory, cardiovascular, and other systems.

Qing Lin

Roger A. Johns

AJP Lung Cellular and Molecular Physiology

美国生理学杂志-肺细胞和分子生理学发表原创研究，涵盖细胞和呼吸系统成分的正常和异常功能的分子、细胞和综合方面的广泛范围。感兴趣的领域包括导气道、肺循环、肺内皮细胞和上皮细胞、胸膜、肺中的神经内分泌和免疫细胞、参与控制呼吸的神经细胞以及膈肌和胸肌细胞。该杂志将涵盖的过程包括气体交换、细胞水平的代谢控制、细胞内信号传导、基因表达、基因组学、大分子及其周转、细胞-细胞和细胞-基质相互作用、细胞运动、分泌机制、膜功能、表面活性剂、基质成分、粘液和衬里材料、肺防御、巨噬细胞功能、盐、水和蛋白质的运输、呼吸系统的发育和分化，以及对环境的反应。

The American Journal of Physiology - Lung Cellular and Molecular Physiology publishes original research covering a wide range of molecular, cellular, and integrative aspects of normal and abnormal functions of cells and components of the respiratory system. Areas of interest include the airways, pulmonary circulation, pulmonary endothelial and epithelial cells, pleura, neuroendocrine and immune cells in the lung, neurons involved in the control of breathing, as well as diaphragm and chest muscle cells. The journal encompasses processes such as gas exchange, metabolic control at the cellular level, intracellular signaling, gene expression, genomics, macromolecule turnover, cell-cell and cell-matrix interactions, cell motility, secretory mechanisms, membrane function, surfactants, matrix components, mucus and lining materials, lung defense, macrophage function, transport of salts, water, and proteins, development and differentiation of the respiratory system, and responses to environmental challenges.

《American Journal of Physiology - Lung Cellular and Molecular Physiology》发表原创研究，涵盖细胞和呼吸系统成分的正常与异常功能的分子、细胞及综合方面的广泛内容。研究领域包括气道、肺循环、肺内皮细胞和上皮细胞、胸膜、肺中的神经内分泌和免疫细胞、参与控制呼吸的神经细胞，以及膈肌和胸肌细胞。该杂志涉及的过程包括气体交换、细胞代谢控制、细胞内信号传导、基因表达、基因组学、大分子及其周转、细胞间和细胞-基质相互作用、细胞运动、分泌机制、膜功能、表面活性剂、基质成分、粘液和衬里材料、肺防御、巨噬细胞功能、盐、水和蛋白质的运输、呼吸系统的发育与分化，以及对环境的反应。

American Journal of Physiology - Lung Cellular and Molecular Physiology

American Journal of Physiology-Lung Cellular and Molecular Physiology

Resistin family proteins in pulmonary diseases

The contribution of RELM signaling to the initiation and progression of lung diseases such as pulmonary hypertension, asthma/allergic airway inflammation, chronic obstructive pulmonary disease, fibrosis, cancers, infection, and other acute lung injuries is summarized.

Category	Quartile
医学	2
医学, 生理学	2
医学, 呼吸系统	3

Resistin family proteins in pulmonary diseases

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Journal Info

Category	Quartile
RESPIRATORY SYSTEM	1