Saponins are a large family of amphiphilic glycosides of steroids and triterpenes found in plants and some marine organisms. By expressing a large diversity of structures on both sugar chains and aglycones, saponins exhibit a wide range of biological and pharmacological properties and serve as major active principles in folk medicines, especially in traditional Chinese medicines. Isolation of saponins from natural sources is usually a formidable task due to the microheterogeneity of saponins in Nature. Chemical synthesis can provide access to large amounts of natural saponins as well as congeners for understanding their structure-activity relationships and mechanisms of action. This article presents a comprehensive account on chemical synthesis of saponins. First highlighted are general considerations on saponin synthesis, including preparation of aglycones and carbohydrate building blocks, assembly strategies, and protecting-group strategies. Next described is the state of the art in the synthesis of each type of saponins, with an emphasis on those representative saponins having sophisticated structures and potent biological activities.

You Yang

Stephane Laval

Biao Yu

Advances in Carbohydrate Chemistry and Biochemistry

ADVANCES IN CARBOHYDRATE CHEMISTRY AND BIOCHEMISTRY 自 1945 年成立以来，提供了由研究专家撰写的重要且内容丰富的文章，这些文章将生物化学、有机化学和仪器方法的工业、分析和技术方面与碳水化合物的研究相结合。其文章对碳水化合物化学和生物化学的现状和未来趋势做出了明确的解释。

Since its establishment in 1945, Advances in Carbohydrate Chemistry and Biochemistry has published numerous important and content-rich articles written by research experts. These articles integrate the industrial, analytical, and technical aspects of biochemistry, organic chemistry, and instrumental methods with carbohydrate research, clearly explaining the current state and future trends of carbohydrate chemistry and biochemistry.

《Advances in Carbohydrate Chemistry and Biochemistry》自1945年创刊以来，发表了众多由研究专家撰写的重要且内容丰富的文章。这些文章将生物化学、有机化学和仪器方法的工业、分析和技术方面与碳水化合物的研究相结合，清晰地阐述了碳水化合物化学和生物化学的现状及未来趋势。

Category	Quartile
化学	2
化学, 有机化学	2
化学, 生化与分子生物学	3

Chemical Synthesis of Saponins

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