In the absence of an intact interferon (IFN) response, mammals may be susceptible to lethal viral infection. IFNs are secreted cytokines that activate a signal transduction cascade leading to the induction of hundreds of interferon-stimulated genes (ISGs). Remarkably, approximately 10% of the genes in the human genome have the potential to be regulated by IFNs. What do all of these genes do? It is a complex question without a simple answer. From decades of research, we know that many of the protein products encoded by these ISGs work alone or in concert to achieve one or more cellular outcomes, including antiviral defense, antiproliferative activities, and stimulation of adaptive immunity. The focus of this review is the antiviral activities of the IFN/ISG system. This includes general paradigms of ISG function, supported by specific examples in the literature, as well as methodologies to identify and characterize ISG function.

John W. Schoggins

Annual Review of Virology

病毒学年度回顾交流了我们对动物、植物、细菌、古细菌、真菌和原生动物病毒的理解方面的令人兴奋的进展。评论突出了基础病毒学、病毒疾病机制、病毒与宿主相互作用以及对病毒感染的细胞和免疫反应的新思想和新方向，并巩固了病毒作为细胞功能独特有力探针的地位。病毒学年度评论于2016 年发布影响因子为 3.345 的期刊引文报告 (JCR)。

The Annual Review of Virology is an annual journal that communicates exciting advancements in our understanding of viruses affecting animals, plants, bacteria, archaea, fungi, and protozoa. The reviews highlight foundational virology, mechanisms of viral diseases, interactions between viruses and hosts, and new ideas and directions regarding cellular and immune responses to viral infections, reinforcing the status of viruses as unique and powerful probes of cellular function. This journal was first published in 2016 and has an impact factor of 3.345 according to the Journal Citation Reports (JCR).

《Annual Review of Virology》是一本年度期刊，交流了我们对动物、植物、细菌、古细菌、真菌和原生动物病毒理解方面的最新进展。期刊评论了基础病毒学、病毒疾病机制、病毒与宿主相互作用，以及对病毒感染的细胞和免疫反应的新思想和新方向，巩固了病毒作为细胞功能独特而有力的探针的地位。该期刊于2016年发布，影响因子为3.345（期刊引文报告，JCR）。

Category	Quartile
医学	1
医学, 病毒学	1

Interferon-Stimulated Genes: What Do They All Do?

ivySCI AI Smartly Parses PDF, Answers Researchers' Questions, and Helps You Understand Papers in Seconds

Journal Info