The critical closing pressure (CrCP) of the cerebral circulation indicates the value of arterial blood pressure (ABP) at which cerebral blood flow (CBF) approaches zero. Measurements in animals and in humans, have shown that the CrCP is significantly greater than zero. A simple mathematical model, incorporating the effects of arterial elasticity and active wall tension, shows that CrCP can be influenced by several structural and physiological parameters, notably intracranial pressure (ICP) and active wall tension. Due to the non-linear shape of the complete ABP-CBF curve, most methods proposed for estimation of CrCP can only represent the linear range of the pressure-flow (or velocity) relationship. As a consequence, only estimates of apparent CrCP can be obtained, and these tend to be significantly higher than the true CrCP. Estimates of apparent CrCP have been shown to be influenced by arterial PCO2, ICP, cerebral autoregulation, intra-thoracic pressure, and mean ABP. There is a lack of investigation, under well-controlled conditions, to assess whether CrCP is altered in disease states. Studies of the cerebral circulation need to take CrCP into account, to obtain more accurate estimates of cerebrovascular resistance changes, and to reflect the correct dynamic relationship between instantaneous ABP and CBF.

R B Panerai

Medical engineering & physics

MEDICAL ENGINEERING & PHYSICS 为发布生物医学工程的最新发展提供了一个论坛，并反映了该学科的基本多学科性质。该杂志发表深入的评论、科学论文和技术说明。我们的重点包括将物理和工程的基本原理应用于医疗设备和技术的开发，最终目标是提高医疗保健质量。涵盖的主题包括生物力学、生物材料、机械生物学、康复工程、生物医学信号加工和医疗器械开发。 MEDICAL ENGINEERING & PHYSICS 旨在让工程师和临床医生了解最新的医疗保健技术应用。

Medical Engineering and Physics provides an important forum for the latest developments in biomedical engineering, reflecting the multidisciplinary nature of the field. The journal publishes in-depth reviews, scientific papers, and technical notes, focusing on the application of fundamental principles of physics and engineering to the development of medical devices and technologies, with the ultimate goal of improving the quality of healthcare. Topics covered include biomechanics, biomaterials, mechanobiology, rehabilitation engineering, biomedical signal processing, and medical device development. Medical Engineering and Physics aims to keep engineers and clinicians informed about the latest applications of healthcare technologies.

《Medical Engineering and Physics》为生物医学工程的最新发展提供了一个重要的论坛，反映了该学科的多学科特性。该杂志发表深入的评论、科学论文和技术说明，重点在于将物理和工程的基本原理应用于医疗设备和技术的开发，最终目标是提升医疗保健的质量。涵盖的主题包括生物力学、生物材料、机械生物学、康复工程、生物医学信号处理和医疗器械开发。《Medical Engineering and Physics》旨在帮助工程师和临床医生了解最新的医疗技术应用。

Medical Engineering and Physics

Med Eng Phys

The critical closing pressure of the cerebral circulation.

Studies of the cerebral circulation need to take CrCP into account, to obtain more accurate estimates of cerebrovascular resistance changes, and to reflect the correct dynamic relationship between instantaneous ABP and CBF.

Category	Quartile
医学	4
医学, 工程生物医学	4

The critical closing pressure of the cerebral circulation.

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Category	Quartile
ENGINEERING, BIOMEDICAL	3