In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-existing ones, is an essential process for growth and development. Different mechanisms such as vasculogenesis, sprouting, intussusceptive, and coalescent angiogenesis, as well as vessel co-option, vasculogenic mimicry and lymphangiogenesis, underlie the formation of new vasculature. In many pathological conditions, such as cancer, atherosclerosis, arthritis, psoriasis, endometriosis, obesity and SARS-CoV-2(COVID-19), developmental angiogenic processes are recapitulated, but are often done so without the normal feedback mechanisms that regulate the ordinary spatial and temporal patterns of blood vessel formation. Thus, pathological angiogenesis presents new challenges yet new opportunities for the design of vascular-directed therapies. Here, we provide an overview of recent insights into blood vessel development and highlight novel therapeutic strategies that promote or inhibit the process of angiogenesis to stabilize, reverse, or even halt disease progression. In our review, we will also explore several additional aspects (the angiogenic switch, hypoxia, angiocrine signals, endothelial plasticity, vessel normalization, and endothelial cell anergy) that operate in parallel to canonical angiogenesis mechanisms and speculate how these processes may also be targeted with anti-angiogenic or vascular-directed therapies.

Andrew C. Dudley

Arjan W. Griffioen

Angiogenesis

《血管生成》是一本国际同行评审期刊，致力于发表高质量的原创文章和评论，了解在生理和病理条件下调节血管生成的细胞和分子机制。作为代表全方位血管生成研究的快速交流的中心来源，这本多学科期刊发表使用分子、体外、动物模型系统和血管生成疾病临床研究的创新实验研究。血管生成还报道了促进或抑制血管生成的新治疗方法以及疾病诊断和预后的新标志物和技术。

Angiogenesis is an international peer-reviewed journal dedicated to publishing high-quality original research and reviews that explore the cellular and molecular mechanisms regulating angiogenesis under physiological and pathological conditions. As a central source for rapid communication in the field of angiogenesis research, this multidisciplinary journal publishes innovative experimental studies utilizing molecular, in vitro, animal model systems, and clinical research on angiogenesis-related diseases. Angiogenesis also reports on new therapeutic approaches that promote or inhibit angiogenesis, as well as novel biomarkers and techniques for disease diagnosis and prognosis.

《Angiogenesis》是一本国际同行评审期刊，专注于发表高质量的原创研究和评论，探讨在生理和病理条件下调节血管生成的细胞和分子机制。作为血管生成研究的快速交流中心，这本多学科期刊发表基于分子、体外实验、动物模型和临床研究的创新实验成果。《Angiogenesis》还报道了促进或抑制血管生成的新治疗方法，以及疾病诊断和预后的新标志物和技术。

Pathological angiogenesis: mechanisms and therapeutic strategies

An overview of recent insights into blood vessel development is provided and novel therapeutic strategies that promote or inhibit the process of angiogenesis to stabilize, reverse, or even halt disease progression are highlighted.

Category	Quartile
医学	1
医学, 外周血管病	2

Pathological angiogenesis: mechanisms and therapeutic strategies

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Journal Info

Category	Quartile
PERIPHERAL VASCULAR DISEASE	1