Contents 1. Overview of phosphatidylinositol 3 kinases 110 1.1 Involvement of phosphatidylinositol three kinases in human disease 111 2. Role of PI3Kδ in the immune system 112 2.1 Disease due to loss of PI3Kδ signaling 113 2.2 Consequences of loss of PI3Kδ signaling in T cells 121 2.3 Consequences of loss of PI3Kδ signaling in B cells 123 2.4 Consequences of loss of PI3Kδ signaling and innate immunity 124 2.5 Disease due to hyperactivation of PI3Kδ signaling 124 2.6 Effects of PI3Kδ-specific inhibitors in the human immune system 128 3. Summary 130 Acknowledgments 132 References 132

Georgios Sogkas

Ignatius Ryan Adriawan

Natalia Dubrowinskaja

Faranaz Atschekzei

Reinhold Ernst Schmidt

Advances in Immunology

50 多年来，《免疫学进展》为学生和研究人员提供了最新的免疫学信息。您可以继续依靠 ADVANCES IN IMMUNOLOGY 为您提供批判性评论，通过对当前知识和研究的总结和评估来检查对该领域至关重要的主题。文章强调基本概念，但也评估实验方法。

For over 50 years, Advances in Immunology has provided students and researchers with the latest information in immunology. You can continue to rely on Advances in Immunology for critical reviews that examine essential topics in the field through summaries and evaluations of current knowledge and research. The articles emphasize fundamental concepts while also assessing experimental methods.

《免疫学进展》已为学生和研究人员提供了超过50年的最新免疫学信息。您可以继续依赖《Advances in Immunology》为您提供批判性的评论，通过总结和评估当前的知识和研究，深入探讨该领域的重要主题。文章不仅强调基本概念，还评估实验方法。

Category	Quartile
医学	3
医学, 免疫学	3

Homeostatic and pathogenic roles of PI3Kδ in the human immune system

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