In the post-genomic era, post- and co-translational modifications (P/C-TM) of proteins are known as the more essential elements for the activation of protein function. Among these protein modifications, glycosylation is one of the most abundant modifications in eukaryotic cells. The synthesis of glycoproteins with uniform glycan structures is essential for functional analysis of glycoproteins and biochemical research. For that purpose, chemical methods to synthesize glycoproteins with chemically uniform glycan structures have been developed. In this review, we highlight our recent advances in the preparation of homogeneous glycoproteins. Especially, we introduce both semi-synthesis and chemical synthesis of glycoproteins along with semi-synthesis of various complex-type N-glycans for the solid-phase synthesis of glycopeptide-thioesters.

Kota Nomura

Yanbo Liu

Yasuhiro Kajihara

Special Volume in Memory of Hidetoshi Yamada Part 1

ADVANCES IN CARBOHYDRATE CHEMISTRY AND BIOCHEMISTRY 自 1945 年成立以来，提供了由研究专家撰写的重要且内容丰富的文章，这些文章将生物化学、有机化学和仪器方法的工业、分析和技术方面与碳水化合物的研究相结合。其文章对碳水化合物化学和生物化学的现状和未来趋势做出了明确的解释。

Since its establishment in 1945, Advances in Carbohydrate Chemistry and Biochemistry has published numerous important and content-rich articles written by research experts. These articles integrate the industrial, analytical, and technical aspects of biochemistry, organic chemistry, and instrumental methods with carbohydrate research, clearly explaining the current state and future trends of carbohydrate chemistry and biochemistry.

《Advances in Carbohydrate Chemistry and Biochemistry》自1945年创刊以来，发表了众多由研究专家撰写的重要且内容丰富的文章。这些文章将生物化学、有机化学和仪器方法的工业、分析和技术方面与碳水化合物的研究相结合，清晰地阐述了碳水化合物化学和生物化学的现状及未来趋势。

Category	Quartile
化学	2
化学, 有机化学	2
化学, 生化与分子生物学	3

Synthesis of homogeneous glycoproteins with diverse N-glycans

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