Understanding molecular transport in the brain is critical to care and prevention of neurological disease and injury. A key question is whether transport occurs primarily by diffusion, or also by convection or dispersion. Dynamic contrast-enhanced (DCE-MRI) experiments have long reported solute transport in the brain that appears to be faster than diffusion alone, but this transport rate has not been quantified to a physically relevant value that can be compared to known diffusive rates of tracers.In this work, DCE-MRI experimental data is analyzed using subject-specific finite-element models to quantify transport in different anatomical regions across the whole mouse brain. The set of regional effective diffusivities ([Formula: see text]), a transport parameter combining all mechanisms of transport, that best represent the experimental data are determined and compared to apparent diffusivity ([Formula: see text]), the known rate of diffusion through brain tissue, to draw conclusions about dominant transport mechanisms in each region.In the perivascular regions of major arteries, [Formula: see text] for gadoteridol (550 Da) was over 10,000 times greater than [Formula: see text]. In the brain tissue, constituting interstitial space and the perivascular space of smaller blood vessels, [Formula: see text] was 10-25 times greater than [Formula: see text].The analysis concludes that convection is present throughout the brain. Convection is dominant in the perivascular space of major surface and branching arteries (Pe > 1000) and significant to large molecules (> 1 kDa) in the combined interstitial space and perivascular space of smaller vessels (not resolved by DCE-MRI). Importantly, this work supports perivascular convection along penetrating blood vessels.

Lori A. Ray

Martin Pike

Matthew Simon

Jeffrey J. Iliff

Jeffrey J. Heys

Fluids and Barriers of the CNS

FLUIDS AND BARRIERS OF THE CNS 是一本开放获取、同行评审的期刊，考虑所有 CNS 液体和屏障系统在健康和疾病中的手稿。通过脑液和屏障的正常功能维持神经系统内部环境的稳态至关重要为了机体的健康。脑脊液 (CSF) 及其组成、循环和吸收在正常和异常的脑功能中具有多种作用，并且与脑实质间质液和血脑屏障处的神经血管单元密切相关。包括血脑脊液屏障、血脑屏障、血视网膜屏障和血神经屏障在内的中枢神经系统流体和屏障系统执行流体分泌、化学信号传导、物理和化学缓冲、专门的定向运输和促进免疫监视。

Fluids and Barriers of the CNS is an open-access, peer-reviewed journal that focuses on the study of central nervous system (CNS) fluids and barrier systems in health and disease. Cerebrospinal fluid (CSF) and its components, circulation, and absorption play critical roles in normal and abnormal brain function, closely interacting with the neurovascular unit at the brain parenchyma interstitial fluid and the blood-brain barrier. The fluid and barrier systems of the central nervous system, including the blood-cerebrospinal fluid barrier, blood-brain barrier, blood-retinal barrier, and blood-nerve barrier, are responsible for fluid secretion, chemical signaling, physical and chemical buffering, specialized directional transport, and facilitating immune surveillance, all of which are essential for maintaining the homeostasis of the internal environment of the nervous system.

《Fluids and Barriers of the CNS》是一本开放获取、同行评审的期刊，专注于中枢神经系统（CNS）液体和屏障系统在健康与疾病中的研究。脑脊液（CSF）及其成分、循环和吸收在正常和异常脑功能中发挥着重要作用，并与脑实质间质液和血脑屏障的神经血管单元密切相关。中枢神经系统的液体和屏障系统，包括血脑脊液屏障、血脑屏障、血视网膜屏障和血神经屏障，负责流体分泌、化学信号传导、物理和化学缓冲、特定的定向运输以及促进免疫监视，这些功能对于维持神经系统内部环境的稳态至关重要。

Fluids Barriers CNS

Quantitative analysis of macroscopic solute transport in the murine brain

This work analyzes DCE-MRI experimental data using subject-specific finite-element models to quantify transport in different anatomical regions across the whole mouse brain and concludes that convection is present throughout the brain.

Category	Quartile
医学	1
医学, 神经科学	2

Quantitative analysis of macroscopic solute transport in the murine brain

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