A series of chalcone derivatives containing indanone were designed and synthesized by aldehyde-ketone condensation and etherification. The activity test demonstrated that the majority of the compounds had good therapeutic and protective activities against tobacco mosaic virus (TMV) at a concentration of 500 μg/mL when being tested. Among them, the target compounds N2 and N7 showed good therapeutic activities against TMV with EC50 values of 70.7 and 89.9 μg/mL, respectively, which were better than that of ningnanmycin (158.3 μg/mL). N2 and N10 showed better protective activities against TMV with EC50 values of 60.8 and 120.3 μg/mL, which were superior to that of ningnanmycin (175.6 μg/mL). A hydrogen bond interaction was observed between N2 and ARG-341 with a bond length of 3.08 Å and a hydrogen bond was observed between ningnanmycin and ASP-66 with a bond length of 3.72 Å. In contrast, the hydrogen bond length of compound N2 was shorter and its binding was closer. Meanwhile, when the heartleaf tobacco was being treated with N2, its increasing rate of malondialdehyde slowed and its content of defense enzymes significantly increased, again reflecting the good activity of N2 against TMV.

Nan Sun

Chenyu Gong

Yuanxiang Zhou

Yuanquan Zhang

Nian Zhang

Li Xing

Wei Xue

ACS Omega

ACS OMEGA 是一个开放获取的全球性科学文章出版物，描述了化学和科学接口领域的新发现，没有对直接影响进行任何感知评估。

ACS Omega is a global open-access scientific journal that focuses on new discoveries in the field of chemistry and its interfaces, without assessing the direct impact of the research.

ACS Omega 是一本开放获取的全球性科学期刊，专注于化学及其相关科学领域的新发现，且不对研究的直接影响进行评估。

Design, Synthesis, and Bioactivity of Chalcone Derivatives Containing Indanone

A series of chalcone derivatives containing indanone were designed and synthesized by aldehyde-ketone condensation and etherification and demonstrated good therapeutic and protective activities against tobacco mosaic virus (TMV) when being tested.

Category	Quartile
化学	3
化学, 化学综合	3

Design, Synthesis, and Bioactivity of Chalcone Derivatives Containing Indanone

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Journal Info

Category	Quartile
CHEMISTRY, MULTIDISCIPLINARY	2