A series of benzothiazole derivatives bearing a 1,3,4-thiadiazole moiety were designed, synthesized and evaluated for their antibacterial, antifungal and antiviral activities. The bioassay results indicated that most of target compounds showed good antiviral activities against tobacco mosaic virus (TMV) and antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo) and Ralstonia solanacearum (Rs). Especially, the anti-Xoo effect of title compounds 5k (N-(5-methoxybenzo[d]thiazol-2-yl)-2-((5-(2-tolyl)-1,3,4-thiadiazol-2-yl)thio)acetamide) and the anti-Rs effect of title compounds 5a (N-(5-nitrobenzo[d]thiazol-2-yl)-2-((5-(4-(trifluorom ethyl)phenyl)-1,3,4-thiadiazol-2-yl)thio)acetmide) respectively reached 52.4% and 71.6% at 100 µg/mL, which are superior to that of bismerthiazol (32.0% and 52.3%). In addition, the protective and inactivation activities of title compound 5i (N-(5-methoxybenzo [d]thiazol-2-yl)-2-((5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl)thio)acetamide) against TMV were 79.5% and 88.3%, respectively, which are better than that of ningnanmycin (76.4% and 86.8%). The above research showed that benzothiazole derivatives bearing a 1,3,4-thiadiazole moiety may be used as potential molecular templates in searching for highly-efficient antiviral and antibacterial agents.

Xu Tang

Zhongbo Wang

Xinmin Zhong

Xiaobin Wang

Lijuan Chen

Ming He

Wei Xue

Phosphorus, sulfur, and silicon and the related elements

磷、硫、硅和相关元素是一份月刊，旨在向在广泛和跨学科的杂原子化学领域工作的人们传播当前趋势和新方法。

Phosphorus, Sulfur and Silicon and the Related Elements is a monthly journal aimed at disseminating current trends and new methodologies to researchers working in the broad and interdisciplinary field of heteroatom chemistry.

《Phosphorus, Sulfur and Silicon and the Related Elements》是一本月刊，旨在向从事广泛和跨学科杂原子化学研究的学者传播最新的趋势和方法。

Category	Quartile
化学	4
化学, 无机化学与核化学	4
化学, 有机化学	4

Synthesis and biological activities of benzothiazole derivatives bearing a 1,3,4-thiadiazole moiety

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Journal Info

Category	Quartile
CHEMISTRY, ORGANIC	3