Iron is an essential nutrient for both humans and pathogenic microbes. Because of its ability to exist in one of two oxidation states, iron is an ideal redox catalyst for diverse cellular processes including respiration and DNA replication. However, the redox potential of iron also contributes to its toxicity; thus, iron concentration and distribution must be carefully controlled. Given the absolute requirement for iron by virtually all human pathogens, an important facet of the innate immune system is to limit iron availability to invading microbes in a process termed nutritional immunity. Successful human pathogens must therefore possess mechanisms to circumvent nutritional immunity in order to cause disease. In this review, we discuss regulation of iron metabolism in the setting of infection and delineate strategies used by human pathogens to overcome iron-withholding defenses.

James E Cassat

Eric P Skaar

Cell host & microbe

CELL HOST & MICROBE 于 2007 年 3 月推出。该杂志的使命是提供一个论坛，供研究微生物的科学家与研究宿主免疫、细胞生物学和通过定植或感染后的分子反应的科学家交流思想和概念。一种微生物。CELL HOST & MICROBE 将发表与微生物（包括细菌、真菌、寄生虫和病毒）相关的新发现，从分子和细胞生物学到转化研究，特别强调微生物与其宿主（脊椎动物、无脊椎动物）之间的界面，或植物；单细胞或多细胞）。统一的主题是对微生物（致病性、非致病性和共生的）与彼此、它们的宿主和它们所居住的细胞环境结合和交流的综合研究。发表在《细胞》上的工作HOST & MICROBE 预计不仅在其领域内具有非凡的意义，而且对周边地区以外的研究人员也很感兴趣。除主要研究手稿外，CELL HOST & MICROBE 还将发表专家分析、评论和对该领域当前感兴趣主题的评论。

Cell Host and Microbe was launched in March 2007. The journal aims to provide a forum for scientists studying microbes to exchange ideas and concepts with those researching host immunity, cell biology, and the molecular responses following colonization or infection by a microbe. Cell Host and Microbe publishes new findings related to microbes, including bacteria, fungi, parasites, and viruses, covering a wide range of topics from molecular and cellular biology to translational research, with a particular emphasis on the interface between microbes and their hosts (vertebrates, invertebrates, or plants). The unifying theme is the comprehensive study of the interactions and communications between microbes (whether pathogenic, non-pathogenic, or symbiotic), each other, their hosts, and the cellular environments they inhabit. Research published in Cell Host and Microbe is expected to be of significant importance not only within its field but also of interest to researchers beyond its immediate scope. In addition to primary research manuscripts, Cell Host and Microbe will also publish expert analyses, reviews, and commentaries on current topics of interest in the field.

《Cell Host and Microbe》于2007年3月创刊。该杂志旨在为研究微生物的科学家与研究宿主免疫、细胞生物学以及微生物在定植或感染后所引发的分子反应的科学家提供一个交流思想和概念的平台。《Cell Host and Microbe》将发表与微生物（包括细菌、真菌、寄生虫和病毒）相关的新发现，涵盖从分子和细胞生物学到转化研究的广泛主题，特别强调微生物与其宿主（脊椎动物、无脊椎动物或植物）之间的相互作用。统一的主题是对微生物（无论是致病性、非致病性还是共生的）与彼此、它们的宿主以及它们所处的细胞环境之间的综合研究。发表在《Cell Host and Microbe》上的研究预计不仅在其领域内具有重要意义，同时也会引起其他相关领域研究人员的兴趣。除了主要研究论文外，《Cell Host and Microbe》还将发表专家分析、评论以及对当前领域热点主题的综述。

Cell Host and Microbe

Cell Host Microbe

Iron in infection and immunity.

Regulation of iron metabolism in the setting of infection is discussed and strategies used by human pathogens to overcome iron-withholding defenses are delineated.

Category	Quartile
医学	1
医学, 微生物学	1
医学, 寄生虫学	1
医学, 病毒学	1

Iron in infection and immunity.

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