Abstract Prostate cancer is one of the most common cancers in the male population. The objective of this investigation was to study the relationship of components of transforming growth factor-B (TGF-β)/phosphoinositide-3-kinases (PI3K)/AKT/mammalian target of rapamycin (mTOR)/nuclear factor kappa B (NF-kB) transduction pathway with clinical-pathological markers. By immunohistochemical methods, we determined the expression of several factors [TGF-β, Transforming Growth Factor B Receptor I (TGFBRI), TGFBRII, PI3K, AKT-Ser, AKT-Thr, mTOR, p-mTOR, inhibitor kB kinase (IKK), pIKK, inhibitor kB (IkB), pIkB, NF-kBp50, and NF-kBp65]. To know their relationship with established classical markers (Preoperative serum prostate specific antigen, pathological tumor stage, clinical tumor stage, Gleason score, perineural invasion, node involvement, positive surgical margins, biochemical progression, and survival) and their importance in the prognosis of biochemical progression, Spearman test, survival analysis, Log-rang test, Kaplan–Meier curves, univariate and multivariate Cox proportional Hazard regression analyses were performed. Spearman analysis showed that there was at least one correlation between TGF-β, TGFBRI, PI3K, pAKT-Thr, p-mTOR, NF-kBp50, and classical markers. Cox multivariate analysis between the prognostic variables (pathological tumor stage, Gleason score, and node involvement) and inmunohistochemical parameters confirmed TGFBR1 and PI3K as a prognostic and independent marker of biochemical progression in prostate cancer. Our results suggest that TGFBR1 and PI3K could be used as useful biomarkers for early diagnosis and prognoses for biochemical recurrence in prostate cancer after radical prostatectomy.

Norelia Torrealba

Raúl Vera

Benito Fraile

Pilar Martínez-Onsurbe

Ricardo Paniagua

Mar Royuela

The Aging Male

《老年男性》是国际老年男性研究学会的官方期刊，是一本涵盖整个衰老过程中男性健康各个方面的多学科出版物。对于有兴趣了解该领域最新发展的任何人来说，该杂志都是一个广受认可和尊重的资源。它每季度出版一次，每年一卷。该杂志发表原创的同行评审研究论文以及评论论文和其他适当的教育材料，为研究人员提供关于这一新兴专业的综合观点。感兴趣的领域包括但不限于：迟发性性腺机能减退的诊断和治疗代谢综合征和相关病症勃起功能障碍和相关疾病的治疗前列腺癌和良性前列腺增生。

Aging Male is the official journal of the International Society for the Study of the Aging Male, covering all aspects of male health throughout the aging process. It is a multidisciplinary publication and serves as a widely recognized and respected resource for anyone interested in the latest developments in this field. The journal is published quarterly, with one volume per year, and features original peer-reviewed research articles, review papers, and other appropriate educational materials, providing researchers with a comprehensive perspective on this emerging specialty. Areas of interest include but are not limited to: the diagnosis and treatment of late-onset hypogonadism, metabolic syndrome and related conditions, treatment of erectile dysfunction and associated diseases, prostate cancer, and benign prostatic hyperplasia.

《Aging Male》是国际老年男性研究学会的官方期刊，涵盖男性在衰老过程中健康的各个方面，是一本多学科的出版物。该杂志是一个广受认可和尊重的资源，适合任何对该领域最新发展感兴趣的人士。它每季度出版一次，每年一卷，发表原创的同行评审研究论文、评论论文以及其他适当的教育材料，为研究人员提供关于这一新兴专业的综合视角。感兴趣的领域包括但不限于：迟发性性腺机能减退的诊断与治疗、代谢综合征及相关病症、勃起功能障碍及相关疾病的治疗、前列腺癌和良性前列腺增生。

Category	Quartile
医学	4
医学, 内分泌学与代谢	4
医学, 泌尿学与肾脏学	4

TGF-β/PI3K/AKT/mTOR/NF-kB pathway. Clinicopathological features in prostate cancer

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Journal Info

Category	Quartile
UROLOGY & NEPHROLOGY	2