Significance: Ferroptosis is featured by the accumulation of polyunsaturated-lipid peroxidation on cellular membranes in an iron-dependent manner. Ferroptosis has been implicated in various pathophysiological processes, including cancer, neurodegeneration, and ischemia-reperfusion tissue injury. However, our understanding about the dynamic and context-specific regulation of ferroptosis remains incomplete. Recent Advances: As the major substrate for peroxidation, the cellular lipidome regulates ferroptosis sensitivity and execution by controlling the abundance and availability of polyunsaturated-lipids for peroxidative modifications. In turn, the cellular lipidome is regulated by a complex network of enzymes and transporters, as well as upstream layers of receptors, kinases, and transcription factors. A number of research has shed light on the link between lipid metabolism and ferroptosis. Here, we summarize our current knowledge on the role of the lipidome and associated protein regulators in various stages of ferroptosis, ranging from initiation, execution to cell death evasion by cells experiencing ferroptotic stress. Critical Issues: This review provides an overview of the mechanisms underlying lipid peroxidation and ferroptosis by discussing the lipid species that directly contribute to lipid peroxidation and ferroptosis, how cells regulate the abundances of these pro-ferroptosis lipids, how lipid peroxidation causes cell death, and how cells prevent and repair membrane lipid damage under ferroptotic conditions. Future Directions: Cell fate regulation in vivo could be different from in vitro culture settings. We envision that a comprehensive and detailed understanding about these important questions in the dynamic regulation of ferroptosis in vivo will accelerate our development of ferroptosis-targeted therapies to improve human health.

Nathchar Naowarojna

Tianshu William Wu

Zijian Pan

Mengyu Li

Jingrong Regina Han

Yilong Zou

Antioxidants and Redox Signaling

抗氧化剂和氧化还原信号 (ARS) 是领先的同行评审期刊，致力于了解氧气和氧化还原 (氧化还原) 过程对人类健康和疾病的重要影响。该杂志探讨了基于遗传、药物和营养氧化还原疗法的关键问题。前沿研究侧重于结构生物学、干细胞、再生医学、表观遗传学、影像学、临床结果以及预防和治疗营养学等领域。ARS 已扩展到在一本期刊中创建两个独特的焦点：ARS DISCOVERIES 和 ARS THERAPEUTICS。 ARS DISCOVERIES（24 期）发表基础和应用研究领域的最高水平突破。 ARS THERAPEUTICS（12 期）是同类出版物中的第一本，它将通过展示氧化还原科学改变健康结果的潜力来帮助增强整个氧化还原生物学领域。ARS 覆盖范围包括：-ROS/RNS 作为信使-气体信号传感器-缺氧和组织氧合-MICRORNA-原核系统-植物生物学的教训

Antioxidants and Redox Signaling is a leading peer-reviewed journal dedicated to understanding the significant impact of oxygen and redox processes on human health and disease. The journal explores key issues related to genetic, pharmacological, and nutritional redox therapies. Cutting-edge research focuses on areas such as structural biology, stem cells, regenerative medicine, epigenetics, imaging, clinical outcomes, and preventive and therapeutic nutrition. The journal has expanded to create two unique focuses: ARS DISCOVERIES and ARS THERAPEUTICS. ARS DISCOVERIES (24 issues) publishes high-level breakthroughs in basic and applied research, while ARS THERAPEUTICS (12 issues) is the first of its kind, aimed at enhancing the entire field of redox biology by showcasing the potential of redox science to improve health outcomes. The scope of ARS includes: - ROS/RNS as messengers - Gas signaling sensors - Hypoxia and tissue oxygenation - MicroRNA - Prokaryotic systems - Lessons from plant biology.

《Antioxidants and Redox Signaling》是一本领先的同行评审期刊，专注于氧气及氧化还原过程对人类健康和疾病的重要影响。该期刊探讨了与遗传、药物和营养相关的氧化还原疗法的关键问题。前沿研究涵盖结构生物学、干细胞、再生医学、表观遗传学、影像学、临床结果以及预防和治疗营养学等领域。期刊分为两个独特的焦点：ARS DISCOVERIES 和 ARS THERAPEUTICS。ARS DISCOVERIES（24期）发表基础和应用研究领域的重大突破，而ARS THERAPEUTICS（12期）是同类出版物中的首个，通过展示氧化还原科学在改善健康结果方面的潜力，推动整个氧化还原生物学领域的发展。ARS的研究范围包括：- ROS/RNS作为信使 - 气体信号传感器 - 缺氧与组织氧合 - 微小RNA - 原核系统 - 植物生物学的启示

Antioxidants &amp; Redox Signaling

Dynamic Regulation of Ferroptosis by Lipid Metabolism

Current knowledge on the role of the lipidome and associated protein regulators in various stages of ferroptosis, ranging from initiation, execution to cell death evasion by cells experiencing ferroPTotic stress are summarized.

Category	Quartile
生物学	2
生物学, 生化与分子生物学	2
生物学, 内分泌学与代谢	2

Dynamic Regulation of Ferroptosis by Lipid Metabolism

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Journal Info

Category	Quartile
ENDOCRINOLOGY & METABOLISM	1