As a subset of CD4+ T cells, regulatory T cells (Tregs) with the characteristic expression of transcription factor FOXP3 play a key role in maintaining self-tolerance and regulating immune responses. However, in some inflammatory circumstances, Tregs can express cytokines of other T help (Th) cells by internal reprogramming, which is called Treg plasticity. These reprogrammed Tregs with impaired suppressive ability contribute to the progression of diseases by secreting pro-inflammatory cytokines. However, in the tumor microenvironment (TME), such changes in phenotype rarely occur in Tregs, on the contrary, Tregs usually display a stronger suppressive function and inhibit anti-tumor immunity. It is important to understand the mechanisms of Treg plasticity in inflammatory diseases and cancers.

Zheng Zhang

Jihua Guo

Rong Jia

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

INFLAMMATION RESEARCH (IR) 发表有关炎症和相关领域各个方面的同行评审论文，包括组织病理学、免疫学机制、基因表达、介质、实验模型、临床研究和药物效果。相关领域定义广泛，包括例如过敏和哮喘、休克、疼痛、关节损伤、皮肤病以及相关药物的临床试验。

The journal "Agents and Actions" publishes peer-reviewed papers on various aspects of inflammation and related fields, including histopathology, immunological mechanisms, gene expression, mediators, experimental models, clinical research, and drug effects. The definition of related fields is broad, encompassing areas such as allergies and asthma, shock, pain, joint injuries, skin diseases, and clinical trials of related drugs.

《Agents and Actions》期刊发表关于炎症及相关领域的同行评审论文，涵盖组织病理学、免疫学机制、基因表达、介质、实验模型、临床研究和药物效果等多个方面。相关领域的定义广泛，包括过敏和哮喘、休克、疼痛、关节损伤、皮肤病以及相关药物的临床试验。

Agents and Actions

Inflamm Res

Treg plasticity and human diseases.

The characteristics of different Th-like Tregs are summarized and the potential mechanisms of these changes in phenotype are discussed, as well as the potential application of drugs or reagents that regulate Treg plasticity in human diseases.

Category	Quartile
医学	3
医学, 细胞生物学	3
医学, 免疫学	3

Treg plasticity and human diseases.

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