Abstract For a long time, hydrogen sulfide (H 2 S) has been considered a toxic compound, but recent studies have found that H 2 S is the third gaseous signaling molecule which plays a vital role in physiological and pathological conditions. Currently, a large number of studies have shown that H 2 S mediates apoptosis through multiple signaling pathways to participate in cancer occurrence and development, for example, PI3K/Akt/mTOR and MAPK signaling pathways. Therefore, the regulation of the production and metabolism of H 2 S to mediate the apoptotic process of cancer cells may improve the effectiveness of cancer treatment. In this review, the role and mechanism of H 2 S in cancer cell apoptosis in mammals are summarized.

Wei Gao

Ya-Fang Liu

Yan-Xia Zhang

Yan Wang

Yu-Qing Jin

Hang Yuan

Xiao-Yi Liang

Xin-Ying Ji

Qi-Ying Jiang

Dong-Dong Wu

Cell Death Discovery

CELL DEATH DISCOVERY 是一本多学科、国际化、仅限在线的开放获取期刊，致力于发表医学与生物化学、药理学、免疫学、细胞生物学和细胞死亡交叉领域的研究，只要它具有科学性。不受限制地访问 CELL DEATH DISCOVERY 中的研究结果将促进基础科学家和临床医生以及专注于癌症、神经生物学和炎症研究的行业研究人员之间进行动态且高效的对话。作为细胞死亡分化协会 (ADMC) 的官方期刊，《细胞死亡发现》将在《细胞死亡与分化》和《细胞死亡与疾病》的成功基础上发表重要的同行评审原始研究、及时评论和社论评论。《细胞死亡发现》致力于提高研究的可重复性。为此，《细胞死亡发现》与其姊妹期刊《细胞死亡与分化》和《细胞死亡与疾病》一起为科学家、临床医生以及制药和生物技术行业的成员提供了一个独特的论坛。它致力于快速出版与这些主题相关的高质量原创论文，以及针对有争议和科学信息问题的专题（通常是征求意见）评论、编辑通信和偶尔的评论。

Cell Death Discovery is a multidisciplinary, international, online-only open-access journal dedicated to publishing research in the intersecting fields of medicine, biochemistry, pharmacology, immunology, cell biology, and cell death, provided that it is scientifically rigorous. Unrestricted access to the research findings in Cell Death Discovery aims to foster dynamic and efficient dialogue between basic scientists, clinicians, and industry researchers focused on cancer, neurobiology, and inflammation. As the official journal of the Association for Cell Death and Differentiation (ADMC), Cell Death Discovery will build upon the success of Cell Death and Differentiation and Cell Death and Disease by publishing significant peer-reviewed original research, timely reviews, and editorials. Cell Death Discovery is committed to enhancing the reproducibility of research. To this end, it collaborates with its sister journals, Cell Death and Differentiation and Cell Death and Disease, to provide a unique forum for scientists, clinicians, and members of the pharmaceutical and biotechnology industries, facilitating the rapid publication of high-quality original papers related to these themes, as well as topical reviews, editorials, and occasional commentaries on controversial and scientific information issues.

《Cell Death Discovery》是一本多学科、国际化、仅限在线的开放获取期刊，专注于医学、生物化学、药理学、免疫学、细胞生物学及细胞死亡等交叉领域的研究，所有研究均需具备科学性。无障碍访问《Cell Death Discovery》中的研究成果，旨在促进基础科学家、临床医生以及专注于癌症、神经生物学和炎症研究的行业研究人员之间的动态高效对话。作为细胞死亡分化协会（ADMC）的官方期刊，《Cell Death Discovery》将在《Cell Death and Differentiation》和《Cell Death and Disease》的成功基础上，发表重要的同行评审原始研究、及时评论和社论。《Cell Death Discovery》致力于提高研究的可重复性。为此，该期刊与其姊妹期刊《Cell Death and Differentiation》和《Cell Death and Disease》共同为科学家、临床医生以及制药和生物技术行业的成员提供一个独特的论坛，快速出版与这些主题相关的高质量原创论文，以及针对有争议和科学信息问题的专题评论、编辑通信和偶尔的评论。

Cell Death Discov.

The potential role of hydrogen sulfide in cancer cell apoptosis

The role and mechanism of H2S in cancer cell apoptosis in mammals are summarized and the regulation of the production and metabolism of H2S to mediate the apoptotic process of cancer cells may improve the effectiveness of cancer treatment.

Category	Quartile
生物学	2
生物学, 细胞生物学	2

The potential role of hydrogen sulfide in cancer cell apoptosis

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