Abstract Over the years, numerous observational studies have substantiated that various dietary choices have opposing effects on CVD. However, the causal effect has not yet been established. Thus, we conducted a Mendelian randomisation (MR) analysis to reveal the causal impact of dietary habits on CVD. Genetic variants strongly associated with 20 dietary habits were selected from publicly available genome-wide association studies conducted on the UK Biobank cohort ( n 449 210). Summary-level data on CVD were obtained from different consortia ( n 159 836–977 323). The inverse-variance weighted method (IVW) was the primary outcome, while MR-Egger, weighted median and MR Pleiotropy RESidual Sum and Outlier were used to assess heterogeneity and pleiotropy. We found compelling evidence of a protective causal effect of genetic predisposition towards cheese consumption on myocardial infarction (IVW OR = 0·67; 95 % CI = 0·544, 0·826; P = 1·784 × 10 −4 ) and heart failure (IVW OR = 0·646; 95 % CI = 0·513, 0·814; P = 2·135 × 10 −4 ). Poultry intake was found to be a detrimental factor for hypertension (IVW OR = 4·306; 95 % CI = 2·158, 8·589; P = 3·416 × 10 −5 ), while dried fruit intake was protective against hypertension (IVW OR = 0·473; 95 % CI = 0·348, 0·642; P = 1·683 × 10 −6 ). Importantly, no evidence of pleiotropy was detected. MR estimates provide robust evidence for a causal relationship between genetic predisposition to 20 dietary habits and CVD risk, suggesting that well-planned diets may help prevent and reduce the risk of CVD.

Miaomiao Yang

Xiong Gao

Liangzhen Xie

Zhizhan Lin

Xingsheng Ye

Jianyan Ou

Jian Peng

British Journal Of Nutrition

BRITISH JOURNAL OF NUTRITION 是一本领先的国际同行评审期刊，涵盖人类和临床营养、动物营养和营养学基础科学的研究。该杂志承认营养科学的多学科性质，包括来自营养研究的所有专业的材料，包括分子和细胞生物学以及营养基因组学。

The British Journal of Nutrition is a leading international peer-reviewed journal that focuses on research in human and clinical nutrition, animal nutrition, and the fundamental sciences of nutrition. The journal recognizes the multidisciplinary nature of nutritional science, encompassing materials from all specialties within nutritional research, including molecular and cellular biology as well as nutritional genomics.

《British Journal of Nutrition》是一本国际领先的同行评审期刊，专注于人类和临床营养、动物营养以及营养学基础科学的研究。该期刊承认营养科学的多学科特性，涵盖来自营养研究各个领域的研究成果，包括分子和细胞生物学以及营养基因组学。

British Journal of Nutrition

Br J Nutr

Causal associations between dietary habits and CVD: a Mendelian randomisation study

MR estimates provide robust evidence for a causal relationship between genetic predisposition to 20 dietary habits and CVD risk, suggesting that well-planned diets may help prevent and reduce the risk of CVD.

Category	Quartile
医学	3
医学, 营养学	3

Causal associations between dietary habits and CVD: a Mendelian randomisation study

ivySCI AI Smartly Parses PDF, Answers Researchers' Questions, and Helps You Understand Papers in Seconds

Journal Info