Contents 1. Introduction 2. Toward in vivo profiling of AD 3. Key methodologies in AD research and clinical practice 3.1 Single molecule array (Simoa) 3.2 Chemiluminescence (CLEIA) and electrochemiluminescence (ECLIA) 3.3 Mass spectrometry 4. Core biomarkers of AD 4.1 A: Aβ PET and CSF Aβ42/40 4.2 T: CSF p-tau and tau PET 4.3 (N): CSF t-tau, NfL, MRI and FDG PET 4.4 Standardization of the core CSF biomarkers 5. Novel CSF biomarkers of AD pathophysiology 5.1 CSF biomarkers of synaptic pathology 5.2 CSF biomarkers of glial activation and neuroinflammation 6. CSF biomarkers of common co-occurring pathologies 7. The need for inexpensive and less invasive biomarkers 8. Extending to blood-based profiling of AD 8.1 A: Plasma Aβ42/40 8.2 T: Plasma p-tau 8.3 (N): Plasma NfL 8.4 G: Plasma GFAp 8.5 Standardization of plasma biomarkers 9. Conclusion Funding Conflicts of interest References

Joel Simrén

Anders Elmgren

Kaj Blennow

Henrik Zetterberg

Advances in Clinical Chemistry

临床化学卷的进展包含学术界和临床实验室科学领域领先专家的材料。这些评论涵盖了广泛的临床化学学科，包括临床生物标志物探索、尖端微阵列技术、蛋白质组学和基因组学。它是临床化学、分子诊断学、病理学和临床实验室科学从业人员不可或缺的资源和实用指南。

Advances in Clinical Chemistry is a significant journal in the field of clinical chemistry, featuring contributions from leading experts in academia and clinical laboratory sciences. The reviews cover a wide range of topics in clinical chemistry, including the exploration of clinical biomarkers, cutting-edge microarray technologies, proteomics, and genomics. This journal serves as an indispensable resource and practical guide for professionals in clinical chemistry, molecular diagnostics, pathology, and clinical laboratory sciences.

《Advances in Clinical Chemistry》是临床化学领域的重要期刊，涵盖了学术界和临床实验室科学领域的领先专家撰写的研究材料。这些评论涉及广泛的临床化学主题，包括临床生物标志物的探索、前沿的微阵列技术、蛋白质组学和基因组学。该期刊是临床化学、分子诊断学、病理学和临床实验室科学从业人员不可或缺的资源和实用指南。

Category	Quartile
医学	2
医学, 医学实验技术	1

Fluid biomarkers in Alzheimer's disease

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