Introduction 78 2. The Basics 78 2.1. NOE theory 78 2.2. Macromolecular structure determination 83 2.3. Dynamics from relaxation measurements 87 3. Faster and Better 89 3.1. Faster acquisition 90 3.2. NOE peak assignment and structure calculation 92 3.3. Using NOEs without prior peak assignment 95 4. Complexes 97 4.1. The transferred NOE 97 4.2. STD and cross saturation 126 99 4.3. Labelling 100 4.4. Exchange regimes 101 5. Interactions with Water 101 6. NOEs Involving Nuclei Other than 1 H 104 6.1. NOEs involving fluorine 104 6.2. Dynamic nuclear polarisation 104 Abbreviations 105 Acknowledgment 105 References 105

Mike P. Williamson

Annual Reports on NMR Spectroscopy

核磁共振光谱年度报告是专家和非专家熟悉核磁共振光谱新技术和应用的首要手段。本系列还介绍了磁共振成像 (MRI) 研究的最新进展。对于有机、无机、分析和物理化学家、生物化学家、结构生物学家、物理学家以及所有研究和使用 NMR 光谱学的人来说，这是一个宝贵的资源。

The Annual Reports on NMR Spectroscopy serves as a vital resource for both experts and non-experts to familiarize themselves with the latest techniques and applications in nuclear magnetic resonance spectroscopy. This series also covers recent advancements in magnetic resonance imaging (MRI) research. It is an invaluable reference for organic, inorganic, analytical, and physical chemists, biochemists, structural biologists, physicists, and anyone involved in the research and application of NMR spectroscopy.

《Annual Reports on NMR Spectroscopy》是专家和非专家了解核磁共振光谱新技术与应用的重要资源。本系列还涵盖了磁共振成像（MRI）研究的最新进展。对于有机、无机、分析和物理化学家、生物化学家、结构生物学家、物理学家以及所有研究和使用NMR光谱学的人员来说，这是一份极具价值的参考资料。

Category	Quartile
化学	3
化学, 光谱学	3

Chapter 3 Applications of the NOE in Molecular Biology

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