The primary mechanism of telomere elongation in mammals is reverse transcription by telomerase. An alternative (ALT) pathway elongates telomeres by homologous recombination in some cancer cells and during pre-implantation embryo development, when telomere length increases rapidly within a few cell cycles. The maternal and paternal telomeres in the zygote are genetically and epigenetically distinct, with differences in telomere length and in chromatin packaging. We discuss models for how these asymmetries may contribute to telomere regulation during the earliest embryonic cell cycles and suggest directions for future research.

Hyuk-Joon Jeon

Mia T. Levine

Michael A. Lampson

Advances in Anatomy, Embryology and Cell Biology

"Advances in Anatomy, Embryology and Cell Biology" presents critical reviews on all topical fields of normal and experimental anatomy including cell biology. The multi-perspective presentation of morphological aspects of basic biological phenomen in the human constitutes the main focus of the series. The contributions re-evaluate the latest findings and show ways for further research.

"Advances in Anatomy, Embryology and Cell Biology" presents critical reviews on all topical fields of normal and experimental anatomy, including cell biology. The main focus of the series is the multi-perspective presentation of the morphological aspects of basic biological phenomena in humans. Contributors re-evaluate the latest findings and outline directions for further research.

《Advances in Anatomy, Embryology and Cell Biology》期刊提供关于正常和实验解剖学各个领域的关键评论，包括细胞生物学。该系列的主要焦点是多角度展示人类基本生物现象的形态学方面。贡献者重新评估最新发现，并展示进一步研究的方向。

Category	Quartile
生物学	4
生物学, 解剖学与形态学	4
生物学, 细胞生物学	4

Telomere Elongation During Pre-Implantation Embryo Development

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