Introduction 60 2. The CARD8 inflammasome 61 2.1 The inflammasomes 61 2.2 Mechanism of CARD8 inflammasome activation 65 2.3 Regulation of NLRP1 and CARD8 by DPP9 70 2.4 CARD8 functions outside of its activation of the inflammasome 73 3. Activation of the CARD8 inflammasome by the HIV protease (PR) 74 3.1 HIV PR structure and function 75 3.2 Host cell substrates of HIV PR 76 3.3 Activation of CARD8 by HIV PR 79 3.4 Non-nucleoside reverse transcriptase inhibitors (NNRTIs) induce Pyroptosis of HIV-infected cells 80 3.5 Potential impact of NNRTIs on HIV reservoirs 84 4. HIV infection and other inflammasomes 86 5. Future directions 88 Acknowledgments 88 References 88

Kolin M. Clark

Priya Pal

Josh G. Kim

Qiankun Wang

Liang Shan

Advances in Immunology

50 多年来，《免疫学进展》为学生和研究人员提供了最新的免疫学信息。您可以继续依靠 ADVANCES IN IMMUNOLOGY 为您提供批判性评论，通过对当前知识和研究的总结和评估来检查对该领域至关重要的主题。文章强调基本概念，但也评估实验方法。

For over 50 years, Advances in Immunology has provided students and researchers with the latest information in immunology. You can continue to rely on Advances in Immunology for critical reviews that examine essential topics in the field through summaries and evaluations of current knowledge and research. The articles emphasize fundamental concepts while also assessing experimental methods.

《免疫学进展》已为学生和研究人员提供了超过50年的最新免疫学信息。您可以继续依赖《Advances in Immunology》为您提供批判性的评论，通过总结和评估当前的知识和研究，深入探讨该领域的重要主题。文章不仅强调基本概念，还评估实验方法。

Category	Quartile
医学	3
医学, 免疫学	3

The CARD8 inflammasome in HIV infection

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