Truncating TTN variants (TTNtv) are the most common genetic cause of dilated cardiomyopathy (DCM), but the underlying mechanisms are incompletely understood and effective therapeutic strategies are lacking. Here we review recent data that shed new light on the functional consequences of TTNtv and how these effects may vary with mutation location.

Celine F Santiago

Inken G Huttner

Diane Fatkin

Current cardiology reports

该杂志的目的是提供专家对心血管医学当前进展的及时观点。我们还寻求提供评论，突出从大量可用的心血管文献中选出的最近发表的最重要的论文。我们通过任命跨学科主要学科领域的关键权威来实现这一目标。栏目编辑选择由主要专家审查的主题，这些专家强调最近的发展并突出过去一年发表的重要论文。由国际多元化成员组成的编辑委员会建议其国家/地区特别感兴趣的主题，并确保主题是最新的并包括新兴研究。我们还提供该领域知名人士的评论。

Current Cardiology Reports aims to provide timely expert opinions on the latest advancements in cardiovascular medicine. We also seek to offer reviews that highlight the most significant papers recently published from the vast array of cardiovascular literature. This is achieved by appointing key authorities from interdisciplinary fields as section editors, who select topics reviewed by leading experts, emphasizing recent developments and highlighting important papers published in the past year. An editorial board composed of internationally diverse members suggests topics of particular interest to their respective countries/regions, ensuring that the subjects are current and include emerging research. Additionally, we provide commentary from prominent figures in the field.

《Current Cardiology Reports》旨在提供心血管医学领域最新进展的专家观点。我们还希望提供评论，突出从大量心血管文献中选出的最近发表的重要论文。为实现这一目标，我们任命跨学科领域的关键权威作为栏目编辑，选择由主要专家审查的主题，强调最近的发展，并突出过去一年发表的重要论文。由国际多元化成员组成的编辑委员会建议与其国家/地区特别相关的主题，确保这些主题是最新的，并涵盖新兴研究。此外，我们还提供该领域知名人士的评论。

Current Cardiology Reports

Curr Cardiol Rep

Titin-related Cardiomyopathy: Is it a Distinct Disease?

Recent data is reviewed that shed new light on the functional consequences of TTNtv and how these effects may vary with mutation location, and how therapeutic strategies to improve protein handling may be beneficial in some cases.

Category	Quartile
医学	3
医学, 心脏和心血管系统	3

Titin-related Cardiomyopathy: Is it a Distinct Disease?

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Journal Info

Category	Quartile
CARDIAC & CARDIOVASCULAR SYSTEMS	2