E6E7 regulates the HK2 expression in cervical cancer via GSK3β/FTO signal.

Chunyan Liu, Yangyang Li, Changyan Dong, Luyun Qu, Ying Zuo

DOI: 10.1016/j.abb.2022.109389

Journal: Archives of biochemistry and biophysics

It is found that E6E7 oncogene activates the transcription of GSK3β, which can promote the ubiquitination-proteasomal degradation of FTO and reduce the level of Fto protein; FTO inhibits the maturation and translation of HK2 mRNA by retaining HK2 pre-mRNA in the nucleus.