Coumarins are found in higher plants like Rutaceae and Umbelliferae and essential oils of
cinnamon bark, cassia leaf, and lavender oil. Coumarin compounds show different biological properties,
viz antimicrobial, antibacterial, antifungal, antioxidant, antitumor, anti-HIV, antihypertension, anticoagulant,
anticancer, antiviral, anti-inflammatory, analgesics, antidiabetic, anti-depressive, and other bioactive
properties. Coumarin and its derivatives possess anticancer activity against different types of cancers
such as prostate, renal, breast, laryngeal, lung, colon, CNS, leukemia, malignant melanoma. In this review,
current developments of coumarin-based anticancer agents viz simple coumarin, furanocoumarin,
pyranocoumarin, pyrone-substituted coumarin, and their important derivatives have been discussed. The
coumarin-triazole, coumarin-chalcone, coumarin-thiosemicarbazone derivatives, and coumarin-metal
complexes have been found more potent than coumarin. Hence, further study and structural improvement
on coumarin and its derivatives may lead to the design and development of more potent anticancer
agents.

Narayan Bhattarai

Anupa A. Kumbhar

Yuba Raj Pokharel

Paras Nath Yadav

Mini-Reviews in Medicinal Chemistry

MINI-REVIEWS IN MEDICINAL CHEMISTRY 的目的是发表关于药物化学和相关学科近期重要进展的简短评论。MINI-REVIEWS IN MEDICINAL CHEMISTRY 涵盖药物化学的所有领域，包括药物合理设计、合成化学、生物有机化学的发展, 高通量筛选, 组合化学, 药物靶点, 天然产物研究和构效关系研究。MINI-REVIEWS IN MEDICINAL CHEMISTRY 是每一位希望随时了解最新情况的药物和药物化学家的重要期刊。日期与最新和最重要的发展。

The purpose of Mini-Reviews in Medicinal Chemistry is to publish concise reviews on recent significant advances in medicinal chemistry and related disciplines. This journal covers all areas of medicinal chemistry, including rational drug design, synthetic chemistry, developments in bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, natural product research, and structure-activity relationship studies. Mini-Reviews in Medicinal Chemistry is an essential journal for researchers who wish to stay updated on the latest and most important developments in the field.

《Mini-Reviews in Medicinal Chemistry》旨在发表关于药物化学及相关学科近期重要进展的简短评论。该期刊涵盖药物化学的各个领域，包括药物合理设计、合成化学、生物有机化学的发展、高通量筛选、组合化学、药物靶点、天然产物研究和构效关系研究。《Mini-Reviews in Medicinal Chemistry》是每位希望及时了解药物和药物化学最新进展的研究者的重要期刊。

Category	Quartile
医学	3
医学, 药物化学	3

Anticancer Potential of Coumarin and its Derivatives

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