The structure, classification, function, and regulation of matrix metalloproteinases in normal and abnormal wound healing is discussed. Results from key studies suggest that neutrophil-derived matrix metalloproteinase 8 (MMP-8) is the predominant collagenase present in normal healing wounds, and that overexpression and activation of this collagenase may be involved in the pathogenesis of nonhealing chronic leg ulcers. Excessive collagenolytic activity in these chronic wounds is possible because of the reduced levels of tissue inhibitor metalloproteinase 1 (TIMP-1). However, until recently, there have been no studies evaluating levels of matrix metalloproteinase or tissue inhibitors of metalloproteinase activity in chronic diabetic foot wounds. Improving basic knowledge and pharmaceutical intervention in this area ultimately may help clinicians identify and proactively intervene in an effort to prevent normal wounds from becoming chronic. This may prevent the high prevalence of morbidity associated with this significant health problem. (J Am Podiatr Med Assoc 92(1): 12-18, 2002)

David G. Armstrong

Edward B. Jude

Journal of the American Podiatric Medical Association

美国足病医学协会杂志是该协会的官方期刊，是足踝医学领域历史最悠久、被引用次数最多的同行评审期刊。它成立于 1907 年，每年出版 6 次，出版研究报告、病例报告、文献综述、特殊通讯、临床通信、致编辑的信函、书评和各种其他类型的投稿。该期刊被收录在生物医学文献的主要索引和摘要服务中。

The Journal of the American Podiatric Medical Association is the official journal of the American Podiatric Medical Association and is the oldest and most cited peer-reviewed journal in the field of foot and ankle medicine. Established in 1907, it publishes six issues per year, featuring research articles, case reports, literature reviews, special communications, clinical communications, letters to the editor, book reviews, and various other types of submissions. The journal is indexed in major biomedical literature indexing and abstracting services.

《Journal of the American Podiatric Medical Association》是美国足病医学协会的官方期刊，也是足踝医学领域历史最悠久、引用次数最多的同行评审期刊。该期刊成立于1907年，每年出版6期，涵盖研究报告、病例报告、文献综述、特别通讯、临床通信、致编辑的信函、书评及其他多种类型的投稿。该期刊被主要的生物医学文献索引和摘要服务收录。

Category	Quartile
医学	4
医学, 骨科	4

The Role of Matrix Metalloproteinases in Wound Healing

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