15 compounds, including two new ones crepidatuols A (1) and B (2) were isolated from the stems of Dendrobium crepidatum. The planar structures of these compounds were elucidated by spectroscopic methods (NMR, MS, UV, and IR) and comparison with those from literatures. 10 compounds were send for enhancing activities on nerve growth factor (NGF) medicated neurite outgrowth in PC12 cells and the results indicated that crepidatuol A (1), confusarin and 3-(2-acetoxy-5-methoxy)phenylpropanol showed enhancing activities at the concentration of 10.0 µM.

Cheng-Bo Li

Cong Wang

Wei-Wei Fan

Fa-Wu Dong

Feng-Qing Xu

Qin-Li Wan

Huai-Rong Luo

Yu-Qing Liu

Jiang-Miao Hu

Jun Zhou

Natural Products and Bioprospecting

Nat. Prod. Bioprospect.

Chemical components of Dendrobium crepidatum and their neurite outgrowth enhancing activities

石斛属植物Dendrobium crepidatum的化学成分及其促进神经突生长的活性

Category	Quartile
化学	3
化学, 药物化学	3

Chemical components of Dendrobium crepidatum and their neurite outgrowth enhancing activities

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Journal Info

Category	Quartile
CHEMISTRY, MEDICINAL	1