Coumarins are secondary metabolites made up of benzene and α-pyrone rings fused together that can potentially treat various ailments, including cancer, metabolic, and degenerative disorders. Coumarins are a diverse category of both naturally occurring as well as synthesized compounds with numerous biological and therapeutic properties. Coumarins as fluorophores play a key role in fluorescent labeling of biomolecules, metal ion detection, microenvironment polarity detection, and pH detection. This review provides a detailed insight into the characteristics of coumarins as well as their biosynthesis in plants and metabolic pathways. Various synthetic strategies for coumarin core involving both conventional and green methods have been discussed comparing advantages and disadvantages of each method. Conventional methods discussed are Pechmann, Knoevenagel, Perkin, Wittig, Kostanecki, Buchwald-Hartwig, and metal-induced coupling reactions such as Heck and Suzuki, as well as green approaches involving microwave or ultrasound energy. Various pharmacological applications of coumarin derivatives are discussed in detail. The structural features and conditions responsible for influencing the fluorescence of coumarin core are also elaborated.

Deepshikha Gupta

Eksha Guliani

Kiran Bajaj

Topics in Current Chemistry

当前化学主题对现代化学研究的当前和未来趋势进行了批判性评论。涵盖范围是化学科学的所有领域，包括与生物学、医学、物理学和材料科学等相关学科的接口。每个专题合集的目标是为学术界或工业界的非专业读者提供全面的深入了解正在出现的新研究领域，这对更大的科学受众感兴趣。

Topics in Current Chemistry provides critical reviews of current and future trends in modern chemical research. It covers all areas of chemical science, including interfaces with related disciplines such as biology, medicine, physics, and materials science. Each thematic collection aims to offer a comprehensive understanding of emerging research fields for non-specialist readers in academia or industry, appealing to a broader scientific audience.

《Topics in Current Chemistry》对现代化学研究的当前和未来趋势进行了深入的批判性评论。该期刊涵盖化学科学的所有领域，包括与生物学、医学、物理学和材料科学等相关学科的交叉领域。每个专题合集旨在为学术界和工业界的非专业读者提供对新兴研究领域的全面理解，以满足更广泛科学受众的兴趣。

Category	Quartile
化学	2
化学, 化学综合	2

Coumarin—Synthetic Methodologies, Pharmacology, and Application as Natural Fluorophore

ivySCI AI Smartly Parses PDF, Answers Researchers' Questions, and Helps You Understand Papers in Seconds

Journal Info

Category	Quartile
CHEMISTRY, MULTIDISCIPLINARY	1