Apoptosis and inflammation are important cellular processes that are highly regulated through specific protein–protein interactions (PPI). Proteins involved in these signaling cascades often carry PPI domains that belong to the death-domain superfamily. This includes the structurally well-characterized Death Domain (DD), the Death Effector Domain (DED) and the Caspase Recruitment Domain (CARD) subfamilies. Recently, a fourth member of the DD superfamily was identified, the Pyrin Domain (PYD). Based on sequence alignments, homology to other domains occurring in death-signalling pathways, and secondary-structure prediction, the PYD was predicted to have an overall fold similar to other DD superfamily members. Just recently, NMR structures of two PYDs have been determined. The PYD structures not only revealed the DD superfamily fold as previously predicted, but also distinct features that are characteristic exclusively for this subfamily. This review summarizes recent findings and developments regarding structural aspects of the DD superfamily, with a special emphasis on the PPIs of the DD superfamily. To cite this article: A. Kohl, M.G. Grütter, C. R. Biologies 327 (2004).

Andreas Kohl

Markus G. Grütter

Comptes Rendus Biologies

COMPTES RENDUS BIOLOGIES 每月发布涉及所有生物和医学研究领域（生物建模、发育和繁殖生物学、细胞生物学、生物化学、神经科学、免疫学、药理学、生态学等）的通讯。文章最好用英文写成。接受带有英文摘要的法语文章。

Comptes Rendus - Biologies is a monthly journal that publishes communications covering all fields of biological and medical research, including biomodeling, developmental and reproductive biology, cell biology, biochemistry, neuroscience, immunology, pharmacology, and ecology. Articles are preferably written in English, and French articles with English abstracts are also accepted.

《Comptes Rendus - Biologies》是一本每月出版的期刊，涵盖所有生物和医学研究领域，包括生物建模、发育与繁殖生物学、细胞生物学、生物化学、神经科学、免疫学、药理学和生态学等。期刊欢迎用英文撰写的文章，也接受附有英文摘要的法语文章。

Comptes Rendus - Biologies

Fire and death: the pyrin domain joins the death-domain superfamily

This review summarizes recent findings and developments regarding structural aspects of theDD superfamily, with a special emphasis on the PPIs of the DD superfamily.

Category	Quartile
生物学	4
生物学, 生物学	4

Fire and death: the pyrin domain joins the death-domain superfamily

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