Remimazolam, a novel benzodiazepine, is widely used as an anesthetic in endoscopic procedures; however, its effects on cognitive function remain unclear, limiting its broader application in general anaesthesia. Neuroinflammation is a well-established key factor in the etiology and progression of cognitive dysfunction, including conditions such as Alzheimer's disease, Parkinson's disease, postoperative delirium, and postoperative cognitive dysfunction. Preclinical studies have demonstrated that remimazolam exerts anti-inflammatory and neuroprotective effects, and clinical reports indicate a reduced incidence of postoperative delirium in patients treated with remimazolam. Nevertheless, whether remimazolam improves cognitive function through its anti-inflammatory properties remains uncertain. This study aimed to investigate the neuroprotective effects of remimazolam and its underlying mechanism in a lipopolysaccharide (LPS)-induced model of neuroinflammation, neuronal injury, and cognitive dysfunction METHODS: C57BL/6J male mice were administered LPS intraperitoneally to establish a model of neuroinflammation-induced cognitive impairment. A subset of mice received remimazolam via intraperitoneal injection 30minutes prior to LPS administration. Cognitive performance was evaluated using behavioural tests, including the Morris Water Maze (MWM), Novel Object Recognition (NOR) test, and Open Field Test (OFT). Hippocampal tissues were analyzed by haematoxylin-eosin (HE) staining to assess structural changes. Inflammatory markers, including Interleukin (IL)-6, IL-1β, and tumor necrosis factor-α, were quantified using enzyme-linked immunosorbent assay (ELISA) and real-time quantitative PCR. Immunofluorescence was used to detect translocator protein (TSPO) and markers of microglia activation (IBA-1, CD16/32, and CD206).

Leguang Zhou

Mengzhe Xiao

Hongzhao Shi

Wenjie Liu

Lijuan Wang

Shangtao Zhou

Shenghua Chen

Yan Wang

Chengxi Liu

Behavioural Brain Research

BEHAVIORAL BRAIN RESEARCH 是一份国际性的跨学科期刊，致力于发表广泛定义的行为神经科学领域的文章。只要目标是描述行为背后的神经机制，来自包括神经科学、行为科学或认知科学的整个学科范围的贡献都是合适的。因此，研究的范围可以从对脑行为关系的神经生理学、神经解剖学、神经化学或神经药理学分析，包括使用分子遗传学或行为遗传学方法，到涉及使用脑成像技术的研究，再到神经行为学研究。鼓励原创研究、主要方法学进展或新颖概念方法的报告。该杂志还将考虑对选定主题的批评性评论。

Behavioural Brain Research is an international interdisciplinary journal dedicated to publishing articles in the broadly defined field of behavioral neuroscience. Contributions from a wide range of disciplines, including neuroscience, behavioral science, and cognitive science, are welcome as long as the aim is to describe the neural mechanisms underlying behavior. Thus, the scope of research can range from neurophysiological, neuroanatomical, neurochemical, or neuropharmacological analyses of the brain-behavior relationship, including studies using molecular genetics or behavioral genetics methods, to research involving brain imaging techniques, and to studies in neurobehavior. We encourage reports of original research, significant methodological advancements, or novel conceptual approaches. The journal also considers critical reviews on selected topics.

《Behavioural Brain Research》是一本国际跨学科期刊，专注于发表行为神经科学领域的研究文章。只要研究目标是描述行为背后的神经机制，来自神经科学、行为科学或认知科学等各个学科的贡献都是适合的。因此，研究范围可以包括对脑与行为关系的神经生理学、神经解剖学、神经化学或神经药理学的分析，使用分子遗传学或行为遗传学方法的研究，应用脑成像技术的研究，以及神经行为学的研究。我们鼓励原创研究、主要方法学进展或新颖概念的报告。此外，该期刊也欢迎对特定主题的批评性评论。

Category	Quartile
心理学	3
心理学, 行为科学	4
心理学, 神经科学	4

Remimazolam attenuates lipopolysaccharide-induced neuroinflammation and cognitive dysfunction

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