In addition to ATP synthesis, mitochondria are highly dynamic organelles that modulate apoptosis, ferroptosis, and inflammasome activation. Through executing these varied functions, the mitochondria play critical roles in the development and progression of neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, Huntington's disease, and Friedreich ataxia, among others. Impaired mitochondrial biogenesis and abnormal mitochondrial dynamics contribute to mitochondrial dysfunction in these diseases. Additionally, dysfunctional mitochondria play critical roles in signaling for both inflammasome activation and ferroptosis. Therapeutics are being developed to circumvent inflammasome activation and ferroptosis in dysfunctional mitochondria. Targeting these aspects of mitochondrial dysfunction may present viable therapeutic strategies for combatting the neurodegenerative diseases. This review aims to summarize the role of the mitochondria in the development and progression of neurodegenerative diseases and to present current therapeutic approaches that target mitochondrial dysfunction in these diseases.

Joseph Johnson

Elizabeth Mercado-Ayon

Yesica Mercado-Ayon

Yi Na Dong

Sarah Halawani

Lucie Ngaba

David R Lynch

Archives of biochemistry and biophysics

生物化学和生物物理学档案在生物化学和生物物理学的发展领域发表高质量的原创文章和评论。研究领域包括：• 酶和蛋白质的结构、功能、调控。折叠、周转和翻译后加工• 生物氧化、自由基反应、氧化还原信号、加氧酶、P450 反应• 信号转导、受体、膜转运、细胞内信号。细胞和综合代谢。

The Archives of Biochemistry and Biophysics is a journal dedicated to the fields of biochemistry and biophysics, publishing high-quality original research articles and reviews. The areas of research include: the structure, function, and regulation of enzymes and proteins; folding, turnover, and post-translational modifications; biological oxidation, free radical reactions, redox signaling, oxygenases, and P450 reactions; signal transduction, receptors, membrane transport, and intracellular signaling; as well as cellular and integrated metabolism.

《Archives of Biochemistry and Biophysics》是一个专注于生物化学和生物物理学领域的期刊，发表高质量的原创研究文章和评论。研究领域包括：酶和蛋白质的结构、功能及调控；折叠、周转和翻译后加工；生物氧化、自由基反应、氧化还原信号、加氧酶及P450反应；信号转导、受体、膜转运和细胞内信号；细胞及综合代谢。

Archives of Biochemistry and Biophysics

Arch Biochem Biophys

Mitochondrial dysfunction in the development and progression of neurodegenerative diseases.

The role of the mitochondria in the development and progression of neurodegenerative diseases is summarized and current therapeutic approaches that target mitochondrial dysfunction in these diseases are presented.

Category	Quartile
生物学	3
生物学, 生物物理	2
生物学, 生化与分子生物学	3

Mitochondrial dysfunction in the development and progression of neurodegenerative diseases.

ivySCI AI Smartly Parses PDF, Answers Researchers' Questions, and Helps You Understand Papers in Seconds

Journal Info