Abstract Background The association between cerebrovascular disease and cognitive impairment is well known, but the impact of lower extremity arterial disease (LEAD) on neuropsychological performance is less established. Objectives The aim of this study was to investigate the influence of LEAD on cognitive impairment. Materials and Methods A total of 20 patients with LEAD, classified by Fountain’s stage IIB, qualified for revascularization surgery has been included in this prospective study. Neuropsychological assessments have been done using MoCA and CANTAB test. Fifteen patients qualified for hernia surgery, without peripheral artery disease served as a control group. Linear regression model has been applied to assess the connection between LEAD and cognitive impairment. Results Differences between the study groups reach significance in both MoCA and CANTAB test. In MoCA test, patients with LEAD had lower levels of performance in attention ( p = 0.0254), visuospatial/executive ( p = 0.0343) and delayed recall ( p = 0.0032). The mean MoCA score was below 26 points. In CANTAB test, patients with LEAD performed worse in visual memory and learning. After adjusted for common cerebrovascular risk factors, LEAD was significantly correlated with cognitive impairment defined as MoCA score &lt; 26 points. Conclusions Lower extremity artery disease is associated with cognitive impairment independently of cerebrovascular risk factors.

Agnieszka Turowicz

Alina Czapiga

Maciej Malinowski

Tadeusz Dorobisz

Bartłomiej Czapla

Dariusz Janczak

Artery Research

《动脉研究》是动脉结构和生理学研究协会 (ARTERY) 的官方期刊，旨在促进有关动脉结构和功能的病理生理学、流行病学、检测、调查和治疗的知识的进步和信息的传播。该杂志发表原创研究文章、评论文章、观点、案例研究、致编辑的信、简短的通信和图片。所有提交的材料都经过严格的同行评审程序。

Artery Research is the official journal of the Artery Society (ARTERY), aimed at advancing and disseminating knowledge related to the pathophysiology, epidemiology, detection, investigation, and treatment of arterial structure and function. The journal publishes original research articles, reviews, viewpoints, case studies, letters to the editor, brief communications, and images. All submitted materials undergo a rigorous peer-review process.

《Artery Research》是动脉结构和生理学研究协会 (ARTERY) 的官方期刊，旨在促进对动脉结构和功能的病理生理学、流行病学、检测、调查和治疗等领域知识的传播与发展。该期刊发表原创研究文章、评论、观点、案例研究、致编辑的信件、简短的通讯以及图片。所有提交的稿件均经过严格的同行评审。

Category	Quartile
医学	4
医学, 外周血管病	4

Lower Extremity Artery Disease and Cognitive Impairment

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Journal Info

Category	Quartile
PERIPHERAL VASCULAR DISEASE	4