Abstract: Chronic wounds remain one of the significant burdens to health across the world, mainly in view of diabetes and its natural consequences. This category of lesions includes pressure ulcers, vascular diseases, and surgery-related wounds, which affect millions and pose a major challenge to the healthcare industry. The paper reviews the various physiological mechanisms of wound healing, factors that impede it, and some new treatments emerging at this moment. In contrast, current developments include surgical and non-surgical alternatives like topical dressings, medicated formulations, and skin substitutes. Advanced wound care today covers tissue-engineered skin substitutes, 3D-printed wound dressings, topical medicated formulations, and growth factor-based therapies. These are non-invasive, biocompatible methods that are cost-effective, userfriendly, and more conducive to natural healing than traditional therapies. Hydrogel dressings have high water content to create a moist environment that encourages healing. They also reflect excellent physicochemical and biological properties, which enhance autolytic debridement and reduction of pain due to the moisture retention, biocompatibility, and non-toxicity conferred. Tissue-engineered skin substitutes, comprising allogeneic or autologous cells, wound-healing enhancement bioengineered allogeneic cellular therapies are like the natural skin and encourage regeneration. 3D printing allows the production of customized dressings to aid in better treatment. Newer therapies, including bioengineered allogeneic cellular therapies and fish skin grafting, require more clinical trials to confirm safety and efficacy. With such innovations in wound healing technologies and therapies, the future looks quite promising in managing chronic wounds, enhancing healing, reducing healthcare expenditure, and promoting a better quality of life for patients.

Rohit Sharma

Jan Hruska

Lukas Peter

Kristina Randlova

Kamil Kuca

Current Medicinal Chemistry

目标与范围当前药物化学涵盖药物化学和合理药物设计方面的所有最新和杰出发展。每期都包含一系列及时的深入评论和客座编辑的主题问题，这些问题由该领域的领导者撰写，涵盖了药物化学的一系列当前主题。该杂志还发表对近期专利的评论。 CURRENT MEDICINAL CHEMISTRY 是每一位希望随时了解最新和最重要进展的药物化学家的重要期刊。

Current Medicinal Chemistry covers all the latest and outstanding developments in the fields of medicinal chemistry and rational drug design. Each issue includes a series of timely in-depth reviews and guest-edited thematic issues written by leaders in the field, covering a range of current topics in medicinal chemistry. The journal also publishes reviews of recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to stay informed about the latest and most significant advancements.

《Current Medicinal Chemistry》涵盖了药物化学和合理药物设计领域的最新和杰出发展。每期都包含一系列及时的深入评论和由该领域领导者撰写的客座编辑主题问题，涉及药物化学的多个当前主题。此外，该杂志还发表对近期专利的评论。《Current Medicinal Chemistry》是每位希望了解药物化学领域最新和重要进展的研究者的重要期刊。

Category	Quartile
医学	4
医学, 生化与分子生物学	3
医学, 药物化学	3
医学, 药学	3

Trends in the Treatment of Chronic Wounds

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Journal Info

Category	Quartile
PHARMACOLOGY & PHARMACY	2