Geographic atrophy (GA), the non-neovascular advanced form of age-related macular degeneration, remains an important disease area in which treatment needs are currently unmet. Recent clinical trials using drugs that target the complement pathway have shown modest yet consistent reductions in GA expansion but without commensurate changes in measures of visual function. In this review, we summarize information from the wide range of studies describing the characteristics of GA morphology and enumerate the factors influencing the growth rates of lesions and the directionality of expansion. In addition, we review the relationship between GA growth and the various measures of vision that reflect changes in function. We consider the reasons for the discordance between the anatomical and functional endpoints in current use and discuss methods to align these key outcomes.

Eleonora M. Lad

Monika Fleckenstein

Frank G. Holz

Liangbo Shen

Lucian V. Del Priore

Rufino Silva

Giovanni Staurenghi

Nadia Waheed

Usha Chakravarthy

Annual Review of Vision Science

视觉科学年度回顾回顾了视觉科学的进展，视觉科学是一组交叉学科，涉及心理学、神经科学、计算机科学、细胞生物学和遗传学以及临床医学。该杂志涵盖了广泛的主题和技术，包括光学、视网膜、中央视觉处理、视觉感知、眼球运动、视觉发育、视觉模型、计算机视觉，以及视觉疾病、功能障碍和视力恢复的机制。视觉研究是许多科学领域取得进展的核心，这本新期刊将探索和揭示将视觉研究与生物学、行为、计算、工程和医学联系起来的联系。

The Annual Review of Vision Science is an annual journal that focuses on the latest advancements in the field of vision science. Vision science is an interdisciplinary field that encompasses psychology, neuroscience, computer science, cell biology, genetics, and clinical medicine. This journal covers a wide range of topics and techniques, including optics, retina, central visual processing, visual perception, eye movements, visual development, visual modeling, computer vision, as well as the mechanisms of visual diseases, disorders, and vision restoration. Vision research plays a central role in the progress of many scientific fields, and this journal aims to explore and reveal the connections between vision research and biology, behavior, computation, engineering, and medicine.

《Annual Review of Vision Science》是一本专注于视觉科学领域的年度回顾期刊，涵盖了视觉科学的最新进展。视觉科学是一个跨学科的领域，涉及心理学、神经科学、计算机科学、细胞生物学、遗传学和临床医学等多个学科。该期刊讨论的主题和技术范围广泛，包括光学、视网膜、中央视觉处理、视觉感知、眼球运动、视觉发育、视觉模型、计算机视觉，以及视觉疾病、功能障碍和视力恢复的机制。视觉研究在多个科学领域的进展中扮演着核心角色，本期刊将探索和揭示视觉研究与生物学、行为、计算、工程和医学之间的联系。

Category	Quartile
医学	2
医学, 眼科学	1
医学, 神经科学	2

Informing Endpoints for Clinical Trials of Geographic Atrophy

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