Abstract Aim To develop standardized diagnostic criteria for ‘infection‐triggered encephalopathy syndrome (ITES)’ and five specific clinical syndromes of ITES. Method The draft definitions were based on existing criteria, standardized, and discussed by a panel of international experts using nominal group technique over 18 months to achieve consensus. All criteria use the same format: (1) presence of infection/fever; (2) clinical features including encephalopathy; (3) neuroradiological features on magnetic resonance imaging; (4) exclusion of other causes. Results We first highlighted differences between ITES and infectious and autoimmune encephalitis, which is the most important differential diagnosis. Consensus was achieved to define five specific ITESs: acute encephalopathy with biphasic seizures and late reduced diffusion; acute necrotizing encephalopathy; mild encephalopathy with a reversible splenial lesion; acute fulminant cerebral oedema; and acute shock with encephalopathy and multiorgan failure. Two further conditions that are currently classified as epilepsy syndromes but have similar features to ITES, namely febrile infection‐related epilepsy syndrome and hemiconvulsion–hemiplegia–epilepsy syndrome, are also discussed. Interpretation The consensus definition is expected to improve awareness of this disease concept, provide diagnostic framework, and facilitate future international research and clinical trials.

Hiroshi Sakuma

Terrence Thomas

Carly Debinski

Michael Eyre

Velda X. Han

Hannah F. Jones

Go Kawano

Vanessa W. Lee

Stephen Malone

Toyojiro Matsuishi

Shekeeb S. Mohammad

Takayuki Mori

Hiroya Nishida

Margherita Nosadini

Jun‐ichi Takanashi

Masashi Mizuguchi

Ming Lim

Russell C. Dale

Developmental Medicine & Child Neurology

WILEY-BLACKWELL 很高兴出版发展医学和儿童神经病学 (DMCN)，这是 MAC KEITH 出版社的出版物，也是美国脑瘫和发育医学学会 (AACPDM) 和英国儿科神经病学协会 (BPNA) 的官方期刊。 超过 50多年来，DMCN定义了儿科神经病学和神经残疾领域，是整个儿科领域的世界领先期刊之一。 DMCN 在全球传播一系列信息，以改善残疾儿童及其家庭的生活。在接受之前，已发表文章的高质量是通过专家评审（包括独立的统计评估）来维持的。

WILEY-BLACKWELL is pleased to publish Developmental Medicine and Child Neurology (DMCN), a publication of MAC KEITH Press and the official journal of the American Academy for Cerebral Palsy and Developmental Medicine (AACPDM) and the British Paediatric Neurology Association (BPNA). For over 50 years, DMCN has defined the fields of paediatric neurology and neurodisability, establishing itself as one of the leading journals in the entire paediatric field. DMCN disseminates a wide range of information globally to improve the lives of children with disabilities and their families. The high quality of published articles is maintained through expert peer review, including independent statistical assessment.

WILEY-BLACKWELL 很高兴出版《Developmental Medicine and Child Neurology》（DMCN），这是 MAC KEITH 出版社的出版物，也是美国脑瘫和发育医学学会（AACPDM）和英国儿科神经病学协会（BPNA）的官方期刊。超过50年来，DMCN在儿科神经病学和神经残疾领域树立了标杆，是全球儿科领域的领先期刊之一。DMCN致力于传播信息，以改善残疾儿童及其家庭的生活。在接受之前，已发表文章的高质量是通过专家评审（包括独立的统计评估）来确保的。

Developmental Medicine and Child Neurology

International consensus definitions for infection‐triggered encephalopathy syndromes

感染触发性脑病综合征国际共识定义

Category	Quartile
医学	2
医学, 儿科	1
医学, 临床神经病学	2

International consensus definitions for infection‐triggered encephalopathy syndromes

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