Improving the efficiency of production to reduce the environmental footprints is pivotal to the sustainability of livestock systems.Despite the advances in cattle feed efficiency (FE) measurement and identification of potential mechanisms involved, much is still unclear regarding the genetic and biological basis of this trait.Nevertheless, lipid and carbohydrate metabolism have been outlined as important in determining efficient and inefficient animals.To address the role of genes partaking in these processes and previously involved with residual feed intake (RFI), we carried out a liver expression profile in Nelore steers (n = 83).Six target genes (FABP1, FADS2, PPP1R26, RGS2, SLC2A5, and UCP2) were measured by qPCR analysis.A general linear mixed model approach was applied to associate them with dry matter intake (DMI), body weight (BW), metabolic BW (MBW, kg), DMI as a percentage of BW (DMI%BW), and average daily gain (ADG, kg/d).Residual feed intake (RFI), feed conversion ratio (FCR), feed efficiency (FE), Kleiber index (KI), and relative growth rate (RGR) were also evaluated.Our results support that increased expression of FABP1 gene was associated with enhanced values for RFI and DMI.Likewise, higher expression level of SLC2A5 was related to higher KI and RGR.There was no phenotypic correlation between RFI and ADG, BW, and MBW.The positive correlations between FABP1 and SLC2A5, and between FABP1 and FADS2 gene expression suggest a putative co-regulation affecting feed efficiency phenotypes.

Wellison J.S. Diniz

Kamila O. da Rosa

Polyana C. Tizioto

Gerson B. Mourão

Priscila S.N. de Oliveira

Marcela M. de Souza

Luciana C.A. Regitano

Agri Gene

Agri Gene publishes papers that focus on the regulation, expression, function and evolution of genes in crop plants, farm animals, and agriculturally important insects and microorganisms.    Agri Gene strives to be a diverse journal and topics in multiple fields will be considered for publication so long as their main focus is on agriculturally important organisms (plants, animals, insects, or microorganisms). Although not limited to the following, some examples of potential topics include:    Gene discovery and characterization.  Genetic markers to guide traditional breeding.  Genetic effects of transposable elements.  Evolutionary genetics, molecular evolution, population genetics, and phylogenetics.  Profiling of gene expression and genetic variation.  Biotechnology and crop or livestock improvement.  Genetic improvement of biological control microorganisms.  Genetic control of secondary metabolic pathways and metabolic enzymes of crop pathogens.  Transcription analysis of beneficial or pest insect developmental stages  Agri Gene encourages submission of novel manuscripts that present a reasonable level of analysis, functional relevance and/or mechanistic insight. Agri Gene also welcomes papers that have predominantly a descriptive component but improve the essential basis of knowledge for subsequent functional studies, or which provide important confirmation of recently published discoveries provided that the information is new.

Agri Gene is a journal that publishes research focused on the regulation, expression, function, and evolution of genes in crop plants, farm animals, and agriculturally important insects and microorganisms. We strive to be a diverse journal, considering submissions from multiple fields as long as they primarily focus on agriculturally important organisms (plants, animals, insects, or microorganisms). Potential topics include, but are not limited to: gene discovery and characterization; genetic markers for guiding traditional breeding; genetic effects of transposable elements; evolutionary genetics, molecular evolution, population genetics, and phylogenetics; profiling of gene expression and genetic variation; biotechnology and improvement of crops or livestock; genetic enhancement of biological control microorganisms; genetic control of secondary metabolic pathways and metabolic enzymes of crop pathogens; and transcription analysis of developmental stages of beneficial or pest insects. Agri Gene encourages the submission of novel manuscripts that present a reasonable level of analysis, functional relevance, and/or mechanistic insight. We also welcome papers that are predominantly descriptive but enhance the essential knowledge base for subsequent functional studies or provide important confirmation of recently published discoveries, provided that the information is new.

《Agri Gene》期刊专注于作物植物、农场动物以及对农业重要的昆虫和微生物中基因的调控、表达、功能和进化等方面的研究。我们致力于成为一个多元化的期刊，欢迎多个领域的主题投稿，只要其主要关注的是农业重要生物（植物、动物、昆虫或微生物）。潜在的研究主题包括但不限于：基因发现与特征分析；指导传统育种的遗传标记；可转座元件的遗传效应；进化遗传学、分子进化、群体遗传学和系统发育学；基因表达和遗传变异的分析；生物技术与作物或牲畜改良；生物防治微生物的遗传改良；作物病原体的次生代谢途径和代谢酶的遗传控制；有益或害虫发育阶段的转录分析。《Agri Gene》鼓励提交具有合理分析水平、功能相关性和/或机制洞察的新颖手稿。我们也欢迎那些主要以描述性内容为主的论文，只要它们能为后续的功能研究提供重要的知识基础，或者提供对最近发表发现的重要确认，只要这些信息是新的。

FABP1 and SLC2A5 expression levels affect feed efficiency-related traits

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