Atherosclerosis is a chronic inflammatory cardiovascular disease, which results from lipid accumulation in the blood vessel wall, forming a plaque, and ultimately restricting blood flow. The immune system plays a vital role in progression to plaque rupture. While recent evidence clearly indicates the anti-inflammatory function of regular exercise, the mechanisms by which regular exercise can modulate its pathophysiology is not well understood. In this review, we discuss how regular exercise can lower systemic inflammation directly via modulation of the immune system or indirectly via altered myokine concentrations and metabolites. We describe the exercise-induced responses of various myokines (such as IL-6, adiponectin, and FGF21), and how cell function in the innate immune system can be modulated via regular exercise, with the aim to modulate plaque formation in atherosclerosis.

André F do Brito Valente

Richard T Jaspers

Rob Ci Wüst

Exercise immunology review

运动免疫学评论 (EIR) 是国际运动与免疫学学会和德国运动医学与预防学会的官方出版物。它致力于发展和丰富与急性运动和定期体育活动相关的免疫学各个方面的知识。 EIR 发表评论文章和具有新的原始数据的论文，包括扩展的、类似评论的讨论。鉴于有助于理解免疫功能的广泛学科，该杂志采用了跨学科重点。这允许传播来自运动科学、医学、免疫学、生理学、行为科学、内分泌学、药理学和心理学等学科的研究成果。

Exercise Immunology Review is the official publication of the International Society of Exercise and Immunology and the German Society of Sports Medicine and Prevention. It is dedicated to advancing and enriching knowledge related to immunology in the context of acute exercise and regular physical activity. The journal publishes review articles and original research papers with new data, including extended discussions similar to reviews. Given the broad disciplines that contribute to understanding immune function, the journal adopts an interdisciplinary focus, allowing for the dissemination of research findings from fields such as exercise science, medicine, immunology, physiology, behavioral science, endocrinology, pharmacology, and psychology.

《Exercise Immunology Review》是国际运动与免疫学学会和德国运动医学与预防学会的官方出版物，致力于发展和丰富与急性运动和定期体育活动相关的免疫学知识。该期刊发表评论文章和包含新原始数据的研究论文，内容涵盖广泛的学科，以帮助理解免疫功能。期刊采用跨学科的重点，传播来自运动科学、医学、免疫学、生理学、行为科学、内分泌学、药理学和心理学等领域的研究成果。

Category	Quartile
医学	4
医学, 免疫学	4
医学, 运动科学	4

Regular physical exercise mediates the immune response in atherosclerosis.

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Journal Info

Category	Quartile
SPORT SCIENCES	1