The power of ribosomes has increasingly been harnessed for the synthesis and selection of molecular libraries. Technologies, such as phage display, yeast display, and mRNA display, effectively couple genotype to phenotype for the molecular evolution of high affinity epitopes for many therapeutic targets. Genetic code expansion is central to the success of these technologies, allowing researchers to surpass the intrinsic capabilities of the ribosome and access new, genetically encoded materials for these selections. Here, we review techniques for the chemical expansion of genetically encoded libraries, their abilities and limits, and opportunities for further development. Importantly, we also discuss methods and metrics used to assess the efficiency of modification and library diversity with these new techniques.

Sabrina E. Iskandar

Victoria A. Haberman

Albert A. Bowers

ACS Combinatorial Science

在新任主编 M.G. 的领导下，《组合化学杂志》以 ACS 组合科学的名义重新发行。斯克里普斯研究所的芬恩。该杂志的特点是扩大了范围，并将建立在组合化学杂志的遗产之上，该杂志是该领域被高度引用的领导者。

Under the leadership of the new editor M.G., the journal "ACS Combinatorial Science" has been relaunched. It is hosted by the Scripps Research Institute's Finn, featuring an expanded scope and building upon the legacy of the Combinatorial Chemistry Journal, which is a highly cited leader in the field.

在新任主编 M.G. 的领导下，《ACS Combinatorial Science》重新发行。该杂志由斯克里普斯研究所的芬恩主办，特色在于扩大了研究范围，并将建立在组合化学杂志的遗产之上，后者是该领域被高度引用的领导者。

Category	Quartile
化学	3
化学, 应用化学	3
化学, 化学综合	3
化学, 药物化学	4

Expanding the Chemical Diversity of Genetically Encoded Libraries

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