Of the thousands of viruses infecting humans, only seven cause cancer in the general population. Tumor sequencing is now a common cancer medicine procedure, and so it seems likely that more human cancer viruses already would have been found if they exist. Here, we review cancer characteristics that can inform a dedicated search for new cancer viruses, focusing on Kaposi sarcoma herpesvirus and Merkel cell polyomavirus as the most recent examples of successful genomic and transcriptomic searches. We emphasize the importance of epidemiology in determining which cancers to examine and describe approaches to virus discovery. Barriers to virus discovery, such as novel genomes and viral suppression of messenger RNA expression, may exist that prevent virus discovery using existing approaches. Optimally virus hunting should be performed in such a way that if no virus is found, the tumor can be reasonably excluded from having an infectious etiology and new information about the biology of the tumor can be found.

Patrick S. Moore

Yuan Chang

Annual Review of Virology

病毒学年度回顾交流了我们对动物、植物、细菌、古细菌、真菌和原生动物病毒的理解方面的令人兴奋的进展。评论突出了基础病毒学、病毒疾病机制、病毒与宿主相互作用以及对病毒感染的细胞和免疫反应的新思想和新方向，并巩固了病毒作为细胞功能独特有力探针的地位。病毒学年度评论于2016 年发布影响因子为 3.345 的期刊引文报告 (JCR)。

The Annual Review of Virology is an annual journal that communicates exciting advancements in our understanding of viruses affecting animals, plants, bacteria, archaea, fungi, and protozoa. The reviews highlight foundational virology, mechanisms of viral diseases, interactions between viruses and hosts, and new ideas and directions regarding cellular and immune responses to viral infections, reinforcing the status of viruses as unique and powerful probes of cellular function. This journal was first published in 2016 and has an impact factor of 3.345 according to the Journal Citation Reports (JCR).

《Annual Review of Virology》是一本年度期刊，交流了我们对动物、植物、细菌、古细菌、真菌和原生动物病毒理解方面的最新进展。期刊评论了基础病毒学、病毒疾病机制、病毒与宿主相互作用，以及对病毒感染的细胞和免疫反应的新思想和新方向，巩固了病毒作为细胞功能独特而有力的探针的地位。该期刊于2016年发布，影响因子为3.345（期刊引文报告，JCR）。

Category	Quartile
医学	1
医学, 病毒学	1

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